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| Description | |
|---|---|
| CatalogueNumber | 07-040 |
| Replaces | 04-232 |
| BrandFamily | Upstate |
| TradeName |
|
| Description | Anti-HDAC4Antibody |
| ProductInformation | |
|---|---|
| Format | Purified |
| Presentation | 0.1MTris-glycine,pH7.4,0.15MNaCl,0.05%sodiumazidebeforetheadditionofglycerolto30% |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | 2yearsat-20°C |
| Applications | |
|---|---|
| Application | Anti-HDAC4AntibodyisaRabbitPolyclonalAntibodyfordetectionofHDAC4alsoknownasHistonedeacetylase4,HD4&hasbeentestedinWB,ICC. |
| KeyApplications |
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| BIOLOGicalInformation | |
|---|---|
| Immunogen | KLH-conjugated,syntheticpeptidecorrespondingtoaminoacids129-137ofhumanHDAC4(C-EHQRKLERH) |
| Host | Rabbit |
| Specificity | HDAC4 |
| Isotype | IgG |
| SpeciesReactivity |
|
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Histonesplayacriticalroleintranscriptionalregulation,cellcycleprogression,anddevelopmentalevents.Histoneacetylation/deacetylationalterschromosomestructureandaffectstranscriptionfactoraccesstoDNA.TheproteinencodedbythisgenebelongstoclassIIofthehistonedeacetylase/acuc/aphafamily.Itpossesseshistonedeacetylaseactivityandrepressestranscriptionwhentetheredtoapromoter.ThisproteindoesnotbindDNAdirectly,butthroughtranscriptionfactorsMEF2CandMEF2D.ItseemstointeractinamultiproteincomplexwithRbAp48andHDAC3. |
| GeneSymbol |
|
| PurificationMethod | ProteinAchromatography |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P56524#ResponsIBLeforthedeacetylationoflysineresiduesontheN-terminalpartofthecorehistones(H2A,H2B,H3andH4).Histonedeacetylationgivesatagforepigeneticrepressionandplaysanimportantroleintranscriptionalregulation,cellcycleprogressionanddevelopmentalevents.Histonedeacetylasesactviatheformationoflargemultiproteincomplexes.InvolvedinmusclematurationviaitsinteractionwiththemyocyteenhancerfactorssuchasMEF2A,MEF2CandMEF2D. SIZE:1084aminoacids;119070Da SUBUNIT:InteractswithHDAC7(Bysimilarity).Homodimer.HomodimerizationviaitsN-terminaldomain.InteractswithMEF2CandNR2C1.Interactswitha14-3-3chaperoneproteininaphosphorylationdependentmanner.InteractswithBTBD14B(Bysimilarity).InteractswithJARID1B. SUBCELLULARLOCATION:Nucleus.Cytoplasm.Note=Shuttlesbetweenthenucleusandthecytoplasm.Uponmusclecellsdifferentiation,itaccumulatesinthenucleiofmyotubes,suggestingapositiveroleofnuclearHDAC4inmuscledifferentiation.Theexporttocytoplasmdependsontheinteractionwitha14-3-3chaperoneproteinandisduetoitsphosphorylationatSer-246,Ser-467andSer-632byCaMK4.Thenuclearlocalizationprobablydependsonsumoylation. TISSUESPECIFICITY:Ubiquitous. DOMAIN:SwissProt:P56524Thenuclearexportsequencemediatestheshuttlingbetweenthenucleusandthecytoplasm. PTM:PhosphorylatedbyCaMK4atSer-246,Ser-467andSer-632.Phosphorylationatotherresiduesisrequiredfortheinteractionwith14-3-3.&SumoylationonLys-559ispromotedbytheE3SUMO-proteinligaseRANBP2,andpreventedbyphosphorylationbyCaMK4. SIMILARITY:Belongstothehistonedeacetylasefamily.Type2subfamily. |
| MolecularWeight | 119kDa |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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