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Epigentek/ACVR1B Polyclonal Antibody, Biotin Conjugated/A58007-050/50 µg

Application:ELISA
AreasofResearch:SignalTransduction
Clonality:Polyclonal
Conjugate:Biotin
Host:Rabbit
Isotype:IgG
Purification:>95%,ProteinGPurified
Reactivity:Human
100%Guarantee:6months
ProductOverview

Background
Transmembraneserine/threoninekinaseactivintype-1receptorforminganactivinreceptorcomplexwithactivinreceptortype-2(ACVR2AorACVR2B).Transducestheactivinsignalfromthecellsurfacetothecytoplasmandisthusregulatingamanyphysiologicalandpathologicalprocessesincludingneuronaldifferentiationandneuronalsurvival,hairfollicledevelopmentandcycling,FSHproductionbythepituitarygland,woundhealing,extracellularmatrixproduction,immunosuppressionandcarcinogenesis.Activinisalsothoughttohaveaparacrineorautocrineroleinfolliculardevelopmentintheovary.Withinthereceptorcomplex,type-2receptors(ACVR2Aand/orACVR2B)actasaprimaryactivinreceptorswhereasthetype-1receptorslikeACVR1Bactasdownstreamtransducersofactivinsignals.Activinbindstotype-2receptorattheplasmamembraneandactivatesitsserine-threoninekinase.Theactivatedreceptortype-2thenphosphorylatesandactivatesthetype-1receptorsuchasACVR1B.Onceactivated,thetype-1receptorbindsandphosphorylatestheSMADproteinsSMAD2andSMAD3,onserineresiduesoftheC-terminaltail.Soonaftertheirassociationwiththeactivinreceptorandsubsequentphosphorylation,SMAD2andSMAD3arereleasedintothecytoplasmwheretheyinteractwiththecommonpartnerSMAD4.ThisSMADcomplextranslocatesintothenucleuswhereitmediatesactivin-inducedtranscription.InhibitorySMAD7,whichisrecruitedtoACVR1BthroughFKBP1A,canpreventtheassociationofSMAD2andSMAD3withtheactivinreceptorcomplex,therebyblockingtheactivinsignal.Activinsignaltransductionisalsoantagonizedbythebindingtothereceptorofinhibin-BviatheIGSF1inhibincoreceptor.ACVR1BalsophosphorylatesTDP2.

Description
ACVR1BPolyclonalAntibody,BiotinConjugated.Biotin.Raisedin:Rabbit.

Formulation
Liquid.0.03%Proclin300,50%Glycerol,0.01MPBS,PH7.4.

Specificity
Human

Isotype
IgG

UniprotID
P36896

Purification
>95%,ProteinGpurified

Immunogen
RecombinanthumanActivinreceptortype-1Bprotein(150-300AA)

Storage
Shippedat4°C.Upondeliveryaliquotandstoreat-20°C(short-term)or-80°C(long-term).Avoidrepeatedfreeze.

AlternativeNames
Activinreceptortype-1B(EC:2.7.11.30),ACVR1B,ACVRLK4,ALK4,ActivinreceptortypeIB,ACTR-IB,Activinreceptor-likekinase4,ALK-4,Serine/threonine-proteinkinasereceptorR2,SKR2

Application
ELISA

VCU0006

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