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Badrilla/Phospholamban (PLN, PLB) mAb (clone A1)/A010-14/25μg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Badrilla/Phospholamban (PLN, PLB) mAb (clone A1)/A010-14/25μg

DESCRIPTION:

Afullyvalidated,highlyspecific,affinitypurifiedmousemonoclonalantibodytophospholamban(PLB,PLN)

Themajorityofcalciumrequiredformusclecontractionismobilisedfromthesarcoplasmicreticulum(SR),towhichithastoreturntoinordertofacilitaterelaxation.The(Ca2+-Mg2+)ATPaseenzymeisresponsIBLeforthesequestrationofcalciumafteritsreleasefromtheSR,andiscontrolledbyphospholamban(PLB)incardiac,smoothandslow-twitchskeletalmuscle.

Themonoclonalantibody(A1)wasraisedagainstbovinecardiacPLB andrecognisesanepitopecomprisingofresidues7LTRSAIRRAS16. TheantibodyreactswithallformsofphospholambanPLB:monomer,oligomers,phosphorylatedandnon-phosphorylated.

TheantibodystimulatesCa2+pumpactivityuponbindingtoPLB,toanextentequivalenttostoichiometricphosphorylationofPLBManipulationofSERCA2:PLBratiosisatherapeuticstrategyforheartfailure.EliminationofPLBboostsSRCa2+-loadwhichcanexacerbatepathologicaloutcomes(apoptosis,arrhythmias)whencombinedwithotheralterationsinSRfunction.

Testedapplications:Westernblot(1:5000dilution),IHCMicroscopy(1:200dilution),Ca2+pumpassays(1:500dilution).


 

DATASHEET:

Description

Lyophilisedrabbitpolyclonalanti-serumcontainingIgGantibodyspecificforser-16phosphorylatedformsofPLB.

Immunogen

Phosphopeptidecomprisingresidues9-19-Y(residuesR9SAIRRAS(PO3H2)TIE19Y)conjugatedtoKLH.

IsotypeIgG
Purification

Rawserum

Speciesreactivity

ReactswithphosphoSer-16ofPLBfromhuman,mouse,rat,rabbit,chicken,ferret,hamsterandsheep.

Testedapplications

WB,ELISAandIHCmicroscopy

Recommendeddilution

WB1:5000

OptimizationOptimaldilutionstobedeterminedbyenduser
Storage

Lyophilisedantibodyisstableat4°Cwhenstoredwithdesiccant.Reconstitutelyophilisedpowderin25µlof18MΩH2O,aliquotandstorefrozenat-80°Cfor1year.Avoidfreeze-thawcycles.

StorageLyophilised:4°CReconstituted:-80°C
DatasheetA010-14
MSDSA010-14
RegulatorystatementProductforresearchuseonly.Notintendedfordiagnosticortherapeuticuse.
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