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Badrilla/SERCA1 mAb (clone B/4H3)/A010-22AP/50 μl188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Badrilla/SERCA1 mAb (clone B/4H3)/A010-22AP/50 μl

DESCRIPTION:

Afullyvalidated,highlyspecificaffinitypurifiedmousemonoclonalantibodytoskeletalmuscleSERCA1

Background:SERCA1istheCa2+-pump(109kDa)locatedinthesarcoplasmicreticulum(SR)offast-twitchskeletalmuscle.Theenzymetransports2Ca2+fromthecytoplasmintotheSRusingthehydrolysisof1moleculeofATPtopowerthereaction.Thisterminatesmusclecontractionandpromotesmusclerelaxation.MutationsintheSERCA1gene(ATP2A1)areobservedinsomepatientswithBrodydisease,anexerciseinducedimpairmentinmusclerelaxtion,stiffnessandcramps.ThemonoclonalantibodyB/4H3wasproducedbyimmunizingmicewithpurifiedSERCA1:theantibodyinhibitsSERCA1activityuponbinding

TestedApplications:WesternBlot(1:5000dilution),IHCMicroscopy(1:200dilution).Speciesrecognition:AntibodytestedonRatandrabbittissue;immunogenicpeptidealignswithMammalianspecies,Avian,AmphibianandFish

DATASHEET:

DescriptionAffinitypurifiedMousemonoclonalantibodytoSERCA1
ImmunogenPurifiedSERCA1a.Epitopewasmappedtoresidues662-666
IsotypeIgG
PurificationProteinAaffinitypurified
SpeciesreactivityAntibodytestedonRatandRabbittissue,butimmunogenicpeptidealignswithMammalianspecies,Avian,AmphibianandFish
TestedapplicationsWB
RecommendeddilutionWB1:5000
OptimizationOptimaldilutionstobedeterminedbyenduser
StorageLyophilisedantibodyisstableat4°Cwhenstoredwithdesiccant.Reconstitutelyophilisedpowderin50µlof18MΩH2O,aliquotandstorefrozenat-80°Cfor1year.Avoidfreeze-thawcycles.
StorageLyophilised:4°C.Reconstituted:-80°C
DatasheetA010-22AP
MSDSA010-22AP
RegulatorystatementProductforresearchuseonly.Notintendedfordiagnosticortherapeuticuse.
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