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Badrilla/Ryanodine receptor 2 (RYR2) (pSer2808) pAb serum/A010-30/50 µl188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Badrilla/Ryanodine receptor 2 (RYR2) (pSer2808) pAb serum/A010-30/50 µl

DESCRIPTION:

Afullyvalidated,highlyspecificrabbitpolyclonalantibodytoRyanodineReceptor2phosphoSerine-2808

TheRyanodineReceptor(RyR2)isaCa2+channelofcardiacmusclethatplaysacentralroleinECcoupling.ThebindingofCa2+ toryanodinereceptor2(RyR2)opensthechannelandCa2+storedintheSRmovesthroughthechannelintothecytosoltoinitiatemusclecontraction.Abnormalstructureandfunctionofryanodinereceptorshasbeenreportedinfailinghearts,withSer-2808phosphorylationappearingelevatedinclinicalsituationswhichmaycontributetotheabnormalCa2+handlingcharacteristicsofcardiacmuscleintheseconditions.Ser-2808canbephosphorylatedinvitrobyPKAorCaMKII,whichiscoincidentwithsignificantchangeinryanodinereceptor2RyR2channelfunctiontypifiedbyanincreasedopenprobABIlity,theabrogationoftheinhibitoryeffectsofCaM,andMg2+,dissociationofregulatoryfactors,expressionofsubconductancestatesandtheexpressionofchannelactivityatdiastolicCa2+concentrations.Serine-2808inhumanRyR2equatestoSer-2809inrabbitRyR2.

Testedapplications: Westernblot(1:5000dilution),IHCMicroscopy(1:100dilution). Speciesrecognition: human,rat,mouse,rabbit,dog,canineandsheep.

 

DATASHEET:

DescriptionLyophilisedRabbitpolyclonalserumcontainingIgGantibodyspecifictoRyR2PhosphoSer-2808.
ImmunogenSyntheticpeptide(YNRTRRIS(PO3H2)QT2810)conjugatedtokeyholelimpethaemocyanin.
IsotypeIgG
PurificationRawserum
SpeciesreactivityTheantibodyrecognisesphosphorylatedSerine-2808oftheryanodinereceptorandbindingisblockedinthepresenceofapeptidecontainingthePhosphoSer-2808epitope.
TestedapplicationsWB,IHC,ELISA
RecommendeddilutionWB1:5000,IHC1:100
OptimizationOptimaldilutionstobedeterminedbyenduser
StorageLyophilisedantibodyisstableat4°Cwhenstoredwithdesiccant.Reconstitutelyophilisedpowderin50µlof18MΩH2O,aliquotandstorefrozenat-80°Cfor1year.Avoidfreeze-thawcycles.
StorageLyophilised:4°CReconstituted:-80°C
DatasheetA010-30Lot1209-03

A010-30Lot0212-03
MSDSA010-30
RegulatorystatementProductforresearchuseonly.Notintendedfordiagnosticortherapeuticuse.
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