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TheRyanodineReceptor(RyR2)isaCa2+channelofcardiacmusclethatplaysacentralroleinECcoupling.ThebindingofCa2+ toryanodinereceptor2(RyR2)opensthechannelandCa2+storedintheSRmovesthroughthechannelintothecytosoltoinitiatemusclecontraction.Abnormalstructureandfunctionofryanodinereceptorshasbeenreportedinfailinghearts,withSer-2808phosphorylationappearingelevatedinclinicalsituationswhichmaycontributetotheabnormalCa2+handlingcharacteristicsofcardiacmuscleintheseconditions.Ser-2808canbephosphorylatedinvitrobyPKAorCaMKII,whichiscoincidentwithsignificantchangeinryanodinereceptor2RyR2channelfunctiontypifiedbyanincreasedopenprobABIlity,theabrogationoftheinhibitoryeffectsofCaM,andMg2+,dissociationofregulatoryfactors,expressionofsubconductancestatesandtheexpressionofchannelactivityatdiastolicCa2+concentrations.Serine-2808inhumanRyR2equatestoSer-2809inrabbitRyR2.
Testedapplications: Westernblot(1:5000dilution),IHCMicroscopy(1:100dilution). Speciesrecognition: human,rat,mouse,rabbit,dog,canineandsheep.
| Description | LyophilisedRabbitpolyclonalserumcontainingIgGantibodyspecifictoRyR2PhosphoSer-2808. |
| Immunogen | Syntheticpeptide(YNRTRRIS(PO3H2)QT2810)conjugatedtokeyholelimpethaemocyanin. |
| Isotype | IgG |
| Purification | Rawserum |
| Speciesreactivity | TheantibodyrecognisesphosphorylatedSerine-2808oftheryanodinereceptorandbindingisblockedinthepresenceofapeptidecontainingthePhosphoSer-2808epitope. |
| Testedapplications | WB,IHC,ELISA |
| Recommendeddilution | WB1:5000,IHC1:100 |
| Optimization | Optimaldilutionstobedeterminedbyenduser |
| Storage | Lyophilisedantibodyisstableat4°Cwhenstoredwithdesiccant.Reconstitutelyophilisedpowderin50µlof18MΩH2O,aliquotandstorefrozenat-80°Cfor1year.Avoidfreeze-thawcycles. |
| Storage | Lyophilised:4°CReconstituted:-80°C |
| Datasheet | A010-30Lot1209-03 A010-30Lot0212-03 |
| MSDS | A010-30 |
| Regulatorystatement | Productforresearchuseonly.Notintendedfordiagnosticortherapeuticuse. |
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