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TheRyanodineReceptor(RyR2)isaCa2+channelofcardiacmusclethatplaysacentralroleinECcoupling.ThebindingofCa2+toryanodinereceptor2RyR2opensthechannelandCa2+storedintheSRmovesthroughthechannelintothecytosoltoinitiatemusclecontraction.CaMKII,wasabletophosphorylateSer-2814ofRYR2enhancingCa2+-sensitivityandincreasingopenprobABIlity.ExcessivephosphorylationofSer-2814leadstoatrialfibrillation,arrhythmiasandsuddendeath.
Testedapplications:Westernblot(1:1000dilution). Speciesrecognition:Allmammalianspecies,whenphosphorylatedonSer-2814(orSer-2815rabbit).
| Description | LyophilisedrabbitpolyclonalIgGantibody(A010-31AP)specifictoRyR2phosphoser-2814 |
| Immunogen | Syntheticpeptide(TSQVS(PO3H2)VDAAH2819)correspondingtoaminoacidssurroundingthephosphorylatedserineresidueatposition2814ofRyR2(human)conjugatedtoKLH. |
| Isotype | IgG |
| Purification | ProteinAaffinitypurified |
| Speciesreactivity | Dog,mouse,human:despiteminordifferencesinsequence,thisantibodyinteractswithantigenbasedonthehumanandmousesequence. |
| Testedapplications | WB.Notyettestedinotherapplications,therefore,optimaldilutions/concentrationsshouldbedeterminedbytheuser.AlsoeffectiveinELISAandIHCmicroscopy. |
| Recommendeddilution | WB1:1000 |
| Optimization | Optimaldilutionstobedeterminedbyenduser |
| Storage | Lyophilisedantibodyisstableat4°Cwhenstoredwithdesiccant.Reconstitutelyophilisedpowderin100µlof18MΩH2O,aliquotandstorefrozenat-80°Cfor1year.Avoidfreeze-thawcycles. |
| Storage | Lyophilised:4°CReconstituted:-80°C |
| Datasheet | A010-31APLot0611-03 A010-31APLot0314-01 |
| MSDS | A010-31AP> |
| Regulatorystatement | Productforresearchuseonly.Notintendedfordiagnosticortherapeuticuse. |
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