产品资料

Hello Bio/SKF 38393 hydrochloride/HB6111/

Name
SKF38393hydrochloride
Shortdescription
Prototypic,selectiveD₁-likereceptorpartialagoNIST
BIOLOGicaldescription
Prototypic,selectiveD₁-likedopaminereceptorpartialagonist(K_ivaluesare1and~0.5nMatD₁-likereceptors(D₁andD₅)and~150,~5000and~1000nMatD₂-likereceptors(D₂,D₃andD₄)respectively).Hydrochloridesalt.

SKF38393facilitateslongtermpotentiation(LTP)viaD₁andD₅activationandhasalsobeenshowntopresynapticallystimulateglutamatereleaseinthehippocampus.
AdditionallyactivatestheHPAaxistoincreaseACTHandcorticosteronelevels.
Showsproconvulsantandanorexiceffects.
Bloodbrainbarrierpermeable.
Activeinvivo.

SKF38393hydrobromidealsoavailable.
Alternativenames
SKF38393
Biologicalaction
Agonist
Purity
>98%
Ourproductsinaction
SubmitYourCitationNow

Chemicalname
(±)-1-Phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diolhydrochloride
MolecularWeight
291.77
Chemicalstructure
MolecularFormula
C₁₆H₁₇NO₂.HCl
CASNumber
62717-42-4
PubChemidentifier
147514
SMILES
C1CNCC(C2=CC(=C(C=C21)O)O)C3=CC=CC=C3.Cl
Source
Synthetic
InChi
InChI=1S/C16H17NO2.ClH/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11;/h1-5,8-9,14,17-19H,6-7,10H2;1H
InChiKey
YEWHJCLOUYPAOH-UHFFFAOYSA-N
MDLnumber
MFCD00069248
Appearance
WhiteSolid

Storageinstructions
-20°C(desiccate)
Solubilityoverview
Solubleinwater(50mM,warming)andinDMSO(100mM)
Important
ThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.

CloningofthegeneforahumandopamineD5receptorwithhigheraffinityfordopaminethanD1.
SunaharaRKetal(1991)Nature350(6319):614-9.
PubMedID:1826762
TheanorecticeffectofSK&F38393,aselectivedopamineD1receptoragonist:amicrostructuralanalysisoffeedingandrelatedbehaviour.
CooperSJetal(1990)Psychopharmacology(Berl):100(2)
PubMedID:1968277
EffectsofquinpiroleandSKF38393aloneandincombinationinsquirrelmonkeystrainedtodiscriminatecocaine.
KatzJLetal(1992)Psychopharmacology(Berl)107(2-3):217-20.
PubMedID:1352052
Dopaminereceptorpharmacology.
SeemanandVanTol(1994)TrendsPharmacolSci.15(5):264-70
PubMedID:7940991
D1/5receptor-mediatedenhancementofLTPrequiresPKA,Srcfamilykinases,andNR2B-containingNMDARs.
StramielloandWagner(2008)Neuropharmacology55(5):871-7
PubMedID:18644393