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Hello Bio/AMTB hydrochloride/HB1167/25mg

Productoverview

  • Name
    AMTBhydrochloride
  • Shortdescription
    TRPM8channelblocker
  • BIOLOGicaldescription
    TRPM8channelblocker(pIC50=6.23).ExhibitsselectivityforTRPM8channelsoverTRPV1andTRPV4channels.Displaysantiproliferativeproperties.
  • Biologicalaction
    Blocker
  • Purity
    >99%
  • Ourproductsinaction
    SubmitYourCitationNow

Properties

  • Chemicalname
    N-(3-Aminopropyl)-2-[(3-methylphenyl)methoxy]-N-(2-thienylmethyl)benzamidehydrochloride
  • MolecularWeight
    430.99
  • Chemicalstructure
    AMTB hydrochloride [926023-82-7]
  • MolecularFormula
    C23H26N2O2S.HCl
  • CASNumber
    926023-82-7
  • PubChemidentifier
    16095383
  • SMILES
    CC1=CC(=CC=C1)COC2=CC=CC=C2C(=O)N(CCCN)CC3=CC=CS3.Cl
  • InChi
    InChI=1S/C23H26N2O2S.ClH/c1-18-7-4-8-19(15-18)17-27-22-11-3-2-10-21(22)23(26)25(13-6-12-24)16-20-9-5-14-28-20;/h4-5,7-11,14-15H,6,12-13,16-17,24H2,1H3;1H
  • InChiKey
    UDXGBANGPYONOK-UHFFFAOYSA-N

StoringandUsingYourProduct

  • Storageinstructions
    Roomtemperature(desiccate)
  • Solubilityoverview
    Solubleinwater(100mM)andinDMSO(100mM)
  • Important
    ThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.

ReferencesforAMTBhydrochloride

  • TRPM8ionchannelsdifferentiallymodulateproliferationandcellcycledistributionofnormalandcancerprostatecells.

    ValeroMLetal(2012)PLoSOne7(12):e51825.
    PubMedID:23251635

  • AMTB,aTRPM8channelblocker:evidenceinratsforactivityinoveractivebladderandpainfulbladdersyndrome.

    LashingerESetal(2008)AmJPhysiolRenalPhysiol295(3):F803-10.
    PubMedID:18562636

  • HumanTRPM8andTRPA1painchannels,includingagenevariantwithincreasedsensitivitytoagoNISTs(TRPA1R797T),exhibitdifferentialregulationbySRC-tyrosinekinaseinhibitor.

    MorganKetal(2014)BiosciRep34(4):
    PubMedID:24975826
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