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Hello Bio/VU 29/HB0642/

Productoverview

  • Name
    VU29
  • Shortdescription
    PotentmGlu5positiveallostericmodulator
  • BIOLOGicaldescription
    PotentmGlu5receptorpositiveallostericmodulator(EC50=9nM).SelectivelypotentiatesmGlu5overmGlu1andmGlu2receptors(EC50valuesare557nMand1.51µMformGlu1andmGlu2receptorsrespectively).ShowsagoNISTicpropertiesforN-TerminaltruncatedmGlu5receptor.CDPPBanalog.
  • Biologicalaction
    PAM
  • Purity
    >99%
  • Ourproductsinaction
    SubmitYourCitationNow

Properties

  • Chemicalname
    N-(1,3-Diphenyl-1H-pyrazolo-5-yl)-4-nitrobenzamide
  • MolecularWeight
    384.39
  • Chemicalstructure
    VU 29 [890764-36-0]
  • MolecularFormula
    C22H16N4O3
  • CASNumber
    890764-36-0

StoringandUsingYourProduct

  • Storageinstructions
    roomtemperature
  • Solubilityoverview
    solubleinDMSO(100mM)
  • Important
    ThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.

ReferencesforVU29

  • Interactionofnovelpositiveallostericmodulatorsofmetabotropicglutamatereceptor5withthenegativeallostericantagonistsiteisrequiredforpotentiationofreceptorresponses.

    ChenYetal(2007)MolPharmacol71(5):1389-98.
    PubMedID:17303702

  • SubstituenteffectsofN-(1,3-diphenyl-1H-pyrazol-5-yl)benzamidesonpositiveallostericmodulationofthemetabotropicglutamate-5receptorinratcorticalastrocytes.

    dePaulisTetal(2006)JMedChem49(11):3332-44.
    PubMedID:16722652

  • mGluR5positiveallostericmodulatorsfacilitatebothhippocampalLTPandLTDandenhancespatiallearning.

    AyalaJEetal(2009)Neuropsychopharmacology34(9):2057-71.
    PubMedID:19295507
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