产品资料

Hello Bio/ω-Conotoxin GVIA/HB1218/100μg

Name
ω-ConotoxinGVIA
Shortdescription
Potent,selectiveCa_v2.2(N-type)channelblocker
BIOLOGicaldescription
Peptidetoxin.Potent,selective,partiallyreversIBLeCa_v2.2(N-type)channelblocker(IC₅₀=0.15nM).BindsCa_v2.2α1subunit(α1B).Inhibitssynapticplasticityandshowshypotensiveandbradycardicactions.
Alternativenames
ω-CTX,ω-CgTx;SNX-124
Biologicalaction
Blocker
Purity
>98%
Netpeptidecontent
73%(thispeptideissoldbygrossweight)
Specialrequirements
Asthisproductisatoxin,customersarerequiredtocompleteashortenduserdeclarationwhenordering.Ourcustomercareteamwillbehappytohelpyouwiththis.
Ourproductsinaction
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Chemicalname
H-Cys(1)-Lys-Ser-Hyp-Gly-Ser-Ser-Cys(2)-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys(3)-Cys(1)-Arg-Ser-Cys(2)-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys(3)-Tyr-NH2trifluoroacetatesalt
MolecularWeight
3037
MolecularFormula
C₁₂₀H₁₈₂N₃₈O₄₃S₆
CASNumber
106375-28-4
PubChemidentifier
16133838
SMILES
C[C@H]([C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@@H](NC(=O)[C@@H]4CSSC[C@@H](C(=O)N[C@H](C(=O)N5C[C@@H](C[C@H]5C(=O)N1)O)CO)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H]6C[C@H](CN6C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N4)CO)CCCNC(=N)N)NC2=O)N)CCCCN)CO)O)CO)CO)CC(=O)N)O)CC7=CC=C(C=C7)O)[C@@H](C)O)CCCCN)CCCNC(=N)N)C(=O)N[C@@H](CC8=CC=C(C=C8)O)C(=O)N)CC(=O)N)CC9=CC=C(C=C9)O)CO)O
InChi
InChI=1S/C120H182N38O43S6/c1-53(165)91-114(197)138-66(10-4-6-26-122)95(178)136-68(12-8-28-132-120(129)130)98(181)149-81(107(190)139-69(93(126)176)29-55-13-19-58(167)20-14-55)49-204-207-52-84-110(193)153-80-48-203-202-47-64(123)94(177)135-65(9-3-5-25-121)9
InChiKey
FDQZTPPHJRQRQQ-NZPQQUJLSA-N
MDLnumber
MFCD00076620

Storageinstructions
-20°C(desiccate)
Solubilityoverview
Solubleinwater(1mg/ml)
Important
ThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.

ComplexstructuresbetweentheN-typecalciumchannel(CaV2.2)andω-conotoxinGVIApredictedviamoleculardynamics.
ChenRetal(2013)Biochemistry52(21):3765-72.
PubMedID:23651160
DistinctmechanismscontributetoagoNISTandsynapticallyinducedmetabotropicglutamatereceptorlong-termdepression.
Connellyetal(2011)EurJPharmacol667(1-3):160-8
PubMedID:21575629
Theeffectofomega-conotoxinGVIAonsynaptictransmissionwithinthenucleusaccumbensandhippocampusoftheratinvitro.
HomeandKemp(1991)BrJPharmacol103(3):1733-9
PubMedID:1657265
omega-Conotoxinreducesfacilitationoftransmitterreleaseatthefrogneuromuscularjunction.
Zengeletal(1993)BrainRes611(1):25-30
PubMedID:8100174