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HumanZyme,Inc.isthegloballeaderprovidinghigh-authenticityrecombinanthumanproteinsfromhumancells.Ourprocessiscost-effectiveandscalablemakingourproteinssuitablefortheresearch,diagnostic,drugdiscoveryandbiopharmaceuticalmarkets. HumanZymeleveragesitsproprietaryengineeredhumancells,expressionvector,andmediumtoensurehigh-yieldproductionofrecombinantproteinswithnativehumanpost-translationalmodifications,suchasphosphorylationandglycosylation.Weareareputableproviderofcytokinesandkinasereagentsandapreferredoutsourcingsupplierofhumanproteinproduction.Ourproductsandservicessupportabroadrangeofcustomersworldwide--fromacademicandgovernmentresearchinstitutionstobiotechnologyandpharmaceuticalcompanies.
Currently,HumanZymeoffersanumberofhigh-authenticityhumanproteincytokines,kinases,andphosphatasesthatconventionalproductionmethodseithercannotproduceorcannoteconomicallyproduce. Wealsoprovidetimelyandcost-effectivecontractproductionofrecombinanthumanproteinsfromhumancells.
HumanCellExpressionSystem:Cost-effectiveandScalableProductionofHigh-authenticityRecombinantHumanProteins
Functionalactivitiesofhumanproteinsdependonproperfolding,phosphorylation,disulfidebridgeformation,andproteolyticprocessingorappropriateglycosylation.Ideally,recombinanthumanproteinsareproducedinhumancellsthataremoreauthenticintermsofbothphysicalpropertiesandbiochemicalfunctions.However,thecurrentprocessofhumancellexpressionrequiresalargequantityofDNAandmediumsupplementedwithbovineserum.Hence,itisoftenadauntingtasktoproducesufficientamountofhighqualityproteinsfordrugdiscoveryordiagnosticdevelopment(1-100mg)atacceptablecost.HumanZymehasdevelopedahighyield,cost-effectiveandversatilesystemtoproduceactiverecombinanthumanproteinsinahumancelllinetomeetthespecialneedsofthebroadscientificcommunityanddrugdiscoveryindustry. Inthissystem,wehavebrokenkeybottleneckstepstoincreaseproteinproductionandreducecost,including:
Usingthisexpressionsystem,wehaveproducedalargenumberofhighlyactivehumancytokines,kinasesandphosphatases.Ourtechnologyisparticularlysuitablefortheproductionofhigh-authenticityhumanproteinsinmediumscaleasresearchanddiagnosticreagents,drugscreeningtargets,andtherapeuticproteinsforpreclinicalevaluation. Keydifferencesofrecombinanthumanproteinproductionindifferentsystemsareillustratedbelow:
Expressionsystem | E.coli | Insectcell | CHOcell | Humancell |
Proteinfolding | + | ++ | +++ | ++++ |
Phosphorylation |
| ++ | +++ | ++++ |
Proteolyticprocessing |
| + | +++ | ++++ |
Glycosylation | - | Poor | Nothuman-like | Authentic |
Typicalglycosylationpatternsbetweenhumanandotherexpressionsystems:
