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StressMarq/Anti-EGFR Antibody (pTyr1069)/SPC-959D-A488/100-µl

Overview:

ProductName EGFRAntibody(pTyr1069)

Description

RabbitAnti-HumanEGFR(pTyr1069)Polyclonal

SpeciesReactivity Human

Applications WB,AM

AntibodyDilution WB(1:250);optimaldilutionsforassaysshouldbedeterminedbytheuser.

HostSpecies Rabbit

ImmunogenSpecies Human

Immunogen Aphospho-specificpeptidecorrespondingtoresiduessurroundingTyr1069ofhumanEGFR(AA1066-1072)

Conjugates

AlkalinePhosphatase,APC,ATTO390,ATTO488,ATTO565,ATTO594,ATTO633,ATTO655,ATTO680,ATTO700,Biotin,FITC,HRP,PE/ATTO594,PerCP,RPE,Streptavidin,Unconjugated

Properties

StorageBuffer	PBSpH7.4,50%glycerol,0.025%Thimerosal
StorageTemperature	-20ºC
ShippingTemperature	BlueIceor4ºC
Purification	PeptideAffinityPurified
Clonality	Polyclonal
Specificity	Detects134.277kDa.
CiteThisProduct	StressMarqBiosciencesCat#SPC-959,RRID:AB_2707661
CertificateofAnalysis	A1:250dilutionofSPC-959wassufficientfordetectionofEGFR(pTyr1069)in10µgofHeLacelllysatebyECLimmunoblotanalysisusinggoatanti-rabbitIgG:HRPasthesecondaryantibody.

BIOLOGicalDescription

AlternativeNames	Avianerythroblasticleukemiaviral(verbb)oncogenehomologAntibody,Cellgrowthinhibitingprotein40Antibody,Cellproliferationinducingprotein61Antibody,Epidermalgrowthfactorreceptor(avianerythroblasticleukemiaviral(verbb)oncogenehomolog)Antibodyy,EpidermalgrowthfactorreceptorAntibody,ERBBAntibody,ERBB1Antibody,ErrpAntibody,HER1Antibody,mENAAntibody,NISBD2Antibodyy,PIG61Antibody,SA7Antibody,wa2Antibody,Wa5Antibody
ResearchAreas	Cancer,CellSignaling,Oncoproteins,ProteinPhosphorylation,ReceptorTyrosineKinases,Receptors,TumorBioMarkers,TyrosineKinases
CellularLocalization	Cellmembrane,EndoplasmicReticulum,Endosome,Golgiapparatus,Nucleus
AccessionNumber	NP_005219
GeneID	1956
SwissProt	P00533
ScientificBackground	EGFRisareceptor-tyrosinekinasethatisactivateduponbindingepidermalgrowthfactor(EGF)andtransforminggrowthfactor-alpha(TGFalpha).BindingofEGFellicitsapro-growthandanti-apoptoticresponsethroughtheRaspathway.Missensemutationsanddeletionsarecommoninavarietyofcancers.

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ATTO488

Overview:

Highfluorescenceyield
HighphotostABIlity
Veryhydrophilic
Excellentsolubilityinwater
Verylittleaggregation
Newdyewithnetchargeof-1
MolarMass:804g/mol

ATTO488Datasheet

ATTO 488 Fluorophore Excitation and Emission Spectra

OpticalProperties:

λ_ex =501nm

λ_em=523nm

ε_max=9.0×10⁴

Φ_f= 0.80

τ_fl =4.1ns

Brightness= 72

Laser = 488 nm