产品资料

StressMarq/Anti-PINX1 Antibody/SPC-1330D-P594/100-µl

Overview:

ProductName PINX1Antibody

Description

RabbitAnti-HumanPINX1Polyclonal

SpeciesReactivity Human

Applications IHC,ELISA

AntibodyDilution IHC(1:100),ELISA(1:20000);optimaldilutionsforassaysshouldbedeterminedbytheuser.

HostSpecies Rabbit

ImmunogenSpecies Human

Immunogen SynthesizedpeptidederivedfrominternalofhumanPINX1.

Conjugates

AlkalinePhosphatase,APC,ATTO390,ATTO488,ATTO565,ATTO594,ATTO633,ATTO655,ATTO680,ATTO700,Biotin,FITC,HRP,PE/ATTO594,PerCP,RPE,Streptavidin,Unconjugated

Properties

StorageBuffer	PBSpH7.4,50%glycerol,150mMNaCl,0.02%sodiumazide
StorageTemperature	-20ºC
ShippingTemperature	BlueIceor4ºC
Purification	AffinityPurified
Clonality	Polyclonal
Isotype	IgG
Specificity	DetectsendogenouslevelsoftotalPINX1protein.
CiteThisProduct	StressMarqBiosciencesCat#SPC-1330,RRID:AB_2713727
CertificateofAnalysis	A1:100dilutionofSPC-1330wassufficientfordetectionofPINX1inhumanhearttissueusingGoatAnti-RabbitIgGasthesecondaryantibody.

BIOLOGicalDescription

AlternativeNames	67-11-3proteinantibody,FLJ20565antibody,Hepatocellularcarcinoma-relatedputativetumorsuppressorantibody,Liver-relatedputativetumorsuppressorantibody,LPTLantibody,LPTSantibody,MGC8850antibody,OTTHUMP00000224984antibody,OTTHUMP00000224985antibody,OTTHUMP00000224986antibody,OTTHUMP00000225053antibody,OTTHUMP00000225054antibody,PIN2interactingprotein1antibody,Pin2-interactingproteinX1antibody,PIN2/TERF1-interactingtelomeraseinhibitor1antibody,PINX1antibody,PINX1_HUMANantibody,Protein67-11-3antibody,TRF1-interactingprotein1antibody
CellularLocalization	Chromosome,Nucleus
AccessionNumber	NP_060354.4
GeneID	54984
SwissProt	Q96BK5
ScientificBackground	PIN2/TERF1-interactingtelomeraseinhibitor1,alsoknownasPINX1,isahumangene.ItmediatesTRF1andTERTaccumulationinnucleolusandenhancesTRF1bindingtotelomeres,inhibitstelomeraseactivity.itmayalsoinhibitcellproliferationandactastumorsuppressor.Over-expressionofPINX1resultsindecreasedtelomeraseactivity,telomereshortening,andinductionofcrisis.ReductionofPINX1leadstoanincreaseintelomeraseactivityandelongationoftelomeres.PINX1differsfromotherproteinsthatregulatetelomerelengthinthatitactsontelomerasewhileotherproteinsadjusttelomerelengthwithoutaffectingtelomeraseactivity.
References	1.SongH.etal.(2004)Biochem.Biophys.Res.Commun.(UnitedStates)316(4):1116–23. 2.Soohoo,C.Y.(2010)JournalofBiologicalChemistry. 3.Yoo,J.E.(2009)JournalofMolecularBiology. 4.Zhou,X.Z.(2011)JournalofClinicalInvestigation.

ProductImages

<p>Immunohistochemistry analysis using Rabbit Anti-PINX1 Polyclonal Antibody (SPC-1330). Tissue: Heart Tissue. Species: Human. Fixation: Formalin fixed paraffin-embedded. Primary Antibody: Rabbit Anti-PINX1 Polyclonal Antibody (SPC-1330) at 1:100. The image on the right is treated with the synthesized peptide.</p>

ImmunohistochemistryanalysisusingRabbitAnti-PINX1PolyclonalAntibody(SPC-1330).Tissue:HeartTissue.Species:Human.Fixation:Formalinfixedparaffin-embedded.PrimaryAntibody:RabbitAnti-PINX1PolyclonalAntibody(SPC-1330)at1:100.Theimageontherightistreatedwiththesynthesizedpeptide.

ProductCitations(0)

Currentlytherearenocitationsforthisproduct.

PE/ATTO594

PE/ATTO594isatandemconjugate,wherePEisexcitedat535nmandtransfersenergytoATTO594viaFRET(fluorescenceresonanceenergytransfer),whichemitsat627nm.

Overview:

Highfluorescenceyield
HighphotostABIlity
Veryhydrophilic
Excellentsolubilityinwater
Verylittleaggregation

PE/ATTO594Datasheet

PE-ATTO 594 Fluorophore Conjugate Excitation and Emission Spectra

OpticalProperties:

λ_ex =535nm

λ_em =627 nm