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The 2H7 antibody reacts with human CD20, expressed by pre-B cells, resting and activated B cells, follicular dendritic cells and a small subset of T cells, but not on plasma cells. CD20 is a 33-37 kDa transmembrane protein which is differentially phosphorylated in resting and active B cells. The CD20 molecule plays a role in regulating B-cell activation.
The 2H7 antibody is reported to be cross-reactive with several non-human species including Baboon, Chimpanzee, Cynomolgus and Rhesus. Please choose the appropriate format for each application.
| Name | violetFluor™ 450 Anti-Human CD20 (2H7) |
|---|---|
| Cat. No. | 75-0209 |
| Alternative Names | B1, Leu-16, Bp35 |
| Gene ID | 931 |
| Clone | 2H7 |
| Isotype | Mouse IgG2b, kappa |
| Reactivity | Human |
| Cross Reactivity | Baboon, Chimpanzee, Cynomolgus, Rhesus, Pigtailed Macaque, Capuchin Monkey, Squirrel Monkey |
| Format | violetFluor™ |
| Applications | Flow Cytometry |
| Citations* | Liu AY, Robinson RR, Murray Jr ED, Ledbetter JA, Hellstrom I and Hellstrom KE. 1987. J Immunol. 139(10): 3521-3526. Schlossman S, Bloumsell L, et al. eds. 1995. Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York. Deans JP, Kalt E, Ledbetter JA, Schieven GL, Bolen JB and Johnson P. 1995. J Biol Chem. 270: 22632-22638. (Flow cytometry) Polyak MJ and Deans JP. 2002. Blood. 99(9): 3256-3262. (Flow cytometry, Immunoprecipitation) Brown KN, Trichel A and Barratt-Boyes SM. 2007. J Immunol. 178(11): 6958-6967. (Flow cytometry - Rhesus) |