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TheSK7antibodyisspecificforhumanCD3e,alsoknownasCD3epsilon,a20kDasubunitoftheTcellreceptorcomplex,alongwithCD3gammaandCD3delta.TheseintegralmembraneproteinchainsassemblewithadditionalchainsoftheTcellreceptor(TCR),aswellasCD3zetachain,toformtheTcellreceptor�CD3complex.Togetherwithco-receptorsCD4orCD8,thecomplexservestorecognizeantigensboundtoMHCmoleculesonantigen-presentingcells.TheseinteractionspromoteTcellreceptorsignaling(Tcellactivation),inducingcellproliferation,differentiation,productionofcytokinesoractivation-inducedcelldeath.CD3isdifferentiallyexpressedduringthymocyte-to-TcelldevelopmentandonallmatureTcells.
TheSK7antibodyisawidelyusedphenotypicMarkerforhumanTcells.ThisantibodymayinduceTcellactivationinthepresenceofmonocytes.Theantibodyhasalsobeendemonstratedtobecross-reactivewithChimpanzeeCD3.BindingofcloneSK7canbeblockedbyanalternativeAnti-HumanCD3clone,OKT3.Pleasechoosetheappropriateformatforeachapplication.
| Name | APC-Cyanine7Anti-HumanCD3(SK7) |
|---|---|
| Cat.No. | 25-0036 |
| AlternativeNames | Leu-4,T3 |
| GeneID | 916 |
| Clone | SK7 |
| Isotype | MouseIgG1,kappa |
| Reactivity | Human |
| CrossReactivity | Chimpanzee |
| Format | APC-Cyanine7 |
| Applications | FlowCytometry |
| Citations* | McMichaelAJ,BeverlyPCL,GilksW,etal,ed.LeukocyteTypingIII:WhiteCellDifferentiationAntigens.NewYork:OxfordUniversityPress;1987. KaneokaH,Perez-RojasG,SasasukiT,BenikeCJandEnglemanEG.1983.JImmunol.131:158–164.(invitroactivation) HaringmanJJ,VinkenoogM,GerlagDM,SmeetsTJM,ZwindermanAHandTakPP.2005.ArthritisResTher.7(4):R862-R867.(Immunohistochemistry–frozentissue) GovalJ-J,GreimersR,BoniverJanddeLevalL.2006.JHistochemCytochem.54(1):75-84.(Immunofluorescence–frozentissue) WrannCD,LaueT,HubnerL,KuhlmannS,JacobsR,GoudevaLandNaveH.2012.AmJPhysiolEndocrinolMetab.302(1):E108-E116.(FlowCytometry) SotoPC,SteinLL,Hurtado-ZiolaN,HedrickSMandVarkiA.2010.JImmunol.184(8):4185-4195.(FlowCytometry–Chimpanzee) |
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