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TheO323antibodyreactswithhumanCD27(TNFRSF7),acellsurfacehomodimerof55kDasubunits,whichprovidesco-stimulatorysignalinginsupportoftheTcell(TCR)andBcell(BCR)receptors.BycomparisonwithCD28,whoseTCRco-stimulatorysignalcantriggercellproliferation,CD27signalingappearstopromotecellsurvivalanddifferentiationtoeffector/memorystages.AlsoincontrastwithCD28,theCD27receptormaybeshedfollowinginteractionwithitsligandCD70,whichistypicallyexpressedonactivateddendriticcells,TcellsandBcells.WithrespecttoBcells,CD27isconsideredtobeaphenotypicMarkerformemoryBcells.CD27hasbeenincludedwithinagroupofphenotypicmarkersforidentifyinghumanBregulatorycells(Bregs),acelltypeproposedtoregulateCD4+TcellproliferationandFoxp3/CTLA-4expressioninTregcells.
TheO323antibodymaybeusedforanalysisofCD27expressiononperipheralTcells,andisfrequentlyusedincombinationwithantibodiesforIgDandIgMtodistinguishnaïvevs.memoryBcellpopulations.ForidentificationofBregcells,thisantibodyhasbeenusedincombinationwithantibodiesforCD25,CD1d,IL-10andTGF-beta(Kesseletal.2012.Autoimm.Rev.11(9):670-677).Theantibodyisalsoreportedforcross-reactivitywithBaboon,CynomolgusandRhesusCD27.
| Name | APCAnti-HumanCD27(O323) |
|---|---|
| Cat.No. | 20-0279 |
| AlternativeNames | TNFRSF7,S152,T14 |
| GeneID | 939 |
| Clone | O323 |
| Isotype | MouseIgG1,kappa |
| Reactivity | Human |
| CrossReactivity | Baboon,Cynomolgus,Rhesus |
| Format | APC |
| Applications | FlowCytometry |
| Citations* | KroenkeMA,EtoD,LocciM,ChoM,DavidsonT,HaddadEK,andCrottyS.2012.J.Immunol.188:3734-3744.(Flowcytometry) RuffellB,AuA,RugoHS,EssermanLJ,HwangES,andCoussensLM.2012.Proc.Natl.Acad.Sci.109:2796-2801.(Flowcytometry) StrowigT,TongvauxA,RathinamC,TakizawaH,BorsottiC,PhilbrickW,EynonEE,Manz,MG,andFlavellRA.2011.Proc.Natl.Acad.Sci.108:13218-13223.(Flowcytometry) SoNSY,OstrowskiMAandGray-OwenSD.2012.J.Immunol.188:4008-4022.(Flowcytometry) KlattNR,VintonCL,LynchRM,CanaryLA,HoJ,DarrahPA,EstesJD,SederRA,MoirSL,andBrenchleyJM.2011.Blood.118:5803-5812.(Cellsorting–Rhesus) AliZ,YanL,PlagmanN,ReichenbergA,HintzM,JomaaH,VillingerF,andChenZW.2009.J.Immunol.183:5407-5417.(Flowcytometry–Rhesus) AliZ,ShaoL,HallidayL,ReichenbergA,HintzM,JomaaH,andChenZW.2007.J.Immunol.8287-8296.(Flowcytometry–Cynomolgus) |
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