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Tonbo Biosciences/APC Anti-Human CD19 (HIB19)/20-0199-T100 /100 tests

TheHIB19antibodyreactswithhumanCD19,a95kDaglycoproteinwhichactsasaco-receptor,alongwithCD21,CD81andCD225,insupportofthefunctionalBcellreceptor(BCR).Thiscomplexprovidesantigen-specificrecognitionandsubsequentactivationofBcellstoproliferateanddifferentiateintoantibody-secretingcells(plasmacells)ormemoryBcells,whicharecrucialforsecondaryantigenencounter.CD19isalineage-differentiationMarker,asitsexpressionisdetectableattheearliestBcellstages,throughdevelopment,andisfinallylostupontransitiontomatureplasmacells.

TheHIB19antibodyiswidelyusedasaphenotypicmarkerforCD19expressiononBcells,aswellasondendriticcellsubsets.

NameAPCAnti-HumanCD19(HIB19)
Cat.No.20-0199
AlternativeNamesLeu-12,B4
GeneID930
CloneHIB19
IsotypeMouseIgG1,kappa
ReactivityHuman
CrossReactivity
FormatAPC
ApplicationsFlowCytometry
Citations*

KroenkeMA,EtoD,LocciM,ChoM,DavidsonT,HaddadEK,andCrottyS.2012.J.Immunol.188:3734-3744.(Flowcytometry)

SoNSY,OstrowskiMA,andGray-OwenSD.2012.J.Immunol.188:4008-4022.(invitrocellcaptureformicroscopy)

ZhangL,YangN,Conejo-GarciaJ-R,KatsarosD,Mohamed-HadleyA,FracchioliS,SchliengerK,TollA,LevineB,RubinSC,andCoukosG.2003.Clin.CancerRes.9:264–272.(Immunohistochemistry)

HibeW,DirnhoferS,OberwasserlechnerF,EistererW,AmmanK,SchmidT,HilbeG,ThalerJ,andWollE.2003.J.Clin.Pathol.56:736-741.(Immunohistochemistry–frozentissues)

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