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The H1.2F3 antibody reacts with mouse CD69, a type II transmembrane glycoprotein also known as the Very Early Activation Antigen, EA-1, Leu23, Activation Inducer Molecule (AIM) and CLEC2C. CD69 is expressed as a 60 kDa disulfide-linked homodimer on activated T and B cells, NK cells, neutrophils and monocytes. Induction occurs rapidly upon activation. It is also constitutively expressed on platelets and a subset of thymocytes. CD69 acts as a co-stimulatory molecule involved in activation and proliferation of T cells, and may be a marker for thymocytes undergoing TCR-mediated positive selection.
Co-stimulation with the H1.2F3 clone has been reported to enhance T cell and macrophage activation. Please choose the appropriate format for each application.
| Name | PE-Cyanine7 Anti-Mouse CD69 (H1.2F3) |
|---|---|
| Cat. No. | 60-0691 |
| Alternative Names | Very Early Activation Antigen (VEA), AIM, EA-1, Leu23, CLEC2C, MLR3, gp34/28 |
| Gene ID | 12515 |
| Clone | H1.2F3 |
| Isotype | Armenian Hamster IgG |
| Reactivity | Mouse |
| Cross Reactivity | No |
| Format | PE-Cyanine7 |
| Applications | Flow Cytometry |
| Citations* | Yamashita I, Nagata T, Tada T and Nakayam T. 1993. Int Immunol. 5(9): 1139-1150. Ziegler SF, Ramsdell F and Alderson MR. 1994. Stem Cells. 12(5): 456-465. Marzio R, Jirillo E, Ransijn A, Mauel J and Corradin SB. 1997. J Leukoc Biol. 62(3): 349-355. Mackay LK, Braun A, Macleaod BL, Collins N, Tebartz C, Bedoui S, Carbone FR and Gebhardt T. 2015. J Immunol. 194(5): 2059-2063. (Flow Cytometry) Radulovic K, Manta C, Rossini V, Holzmann K, Kestler HA, Wegenka UM, Nakayam T and Niess JH. 2012. J Immunol. 188(4): 2001-2013. (Flow Cytometry, in vitro activation) Bremser A, Brack M and Izcue A. 2015. PLoS One. 10(9):e0137393. (Flow Cytometry) Zhou X, Li F, Kong L, Tomita H, Li C and Cao W. 2005. J Biol Chem. 280(35): 31240-31248. (Immunofluorescence Microscopy) |