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The9E10antibodywasgeneratedusingapeptide(EQKLISEEDL)withintheC-terminalregionofhumanc-myc,aproteinexpressedinthecellnucleus,whereitplaysanimportantroleincellcycleregulationandapoptosis.Inaddition,c-mycisconsideredtobeaproto-oncogenicproteinasitisexpressedathigherlevelsinavarietyofhematopoietictumors.The9E10antibodyiswidelyutilizedtopurifyoridentifyrecombinantproteinswhichhavebeenengineeredtoexpressthe9E10epitopetag.
c-myctaggedproteinsmaybeanalyzedbyflowcytometry,WesternBlot,andELISA,amongmanyotherapplications.Theepitopedetectedby9E10ishighlyconserved,allowingthisantibodytobeusedinavarietyofspecies.
| Name | PurifiedAnti-Humanc-Myc(9E10) |
|---|---|
| Cat.No. | 70-6784 |
| AlternativeNames | Mycproto-oncogeneprotein |
| GeneID | 4609 |
| Clone | 9E10 |
| Isotype | MouseIgG1,kappa |
| Reactivity | Human |
| CrossReactivity | |
| Format | Purified |
| Applications | FlowCytometry,ICC,IF,IP,WesternBlot,ElectronMicroscopy |
| Citations* | Stengeletal.2012.Proc.Natl.Acad.Sci.109:5399-5404.(Cellsorting/Flowcytometry) Servantetal.2012.NucleicAcidsRes.40:5271-5282.(Chromatinimmunoprecipitation/ChIP) Mancaetal.2012.Proc.Natl.Acad.Sci.109:2009-2012.(invitroinjection–chickenembryos) Houetal.2012.J.Biol.Chem.287:474-483.(WesternBlot,Immunoprecipitation) Neerincxetal.2012.J.Immunol.188:4940-4950.(Immunofluorescencemicroscopy) Dodsonetal.2012.Hum.Mol.Genet.21:1350-1363.(Immunocytochemistry) Laurentetal.2012.NucleicAcidsRes.40:3159-3171.(RNA–FISHcombinedwithimmunofluorescence) Banfieldetal.1994.J.CellBiol.127:357-371.(Electronmicroscopy) Siegeletal.1998.Int.J.Oncol.13(6):1259-1262.(Westernblot-mouse) |