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TheHIB19antibodyreactswithhumanCD19,a95kDaglycoproteinwhichactsasaco-receptor,alongwithCD21,CD81andCD225,insupportofthefunctionalBcellreceptor(BCR).Thiscomplexprovidesantigen-specificrecognitionandsubsequentactivationofBcellstoproliferateanddifferentiateintoantibody-secretingcells(plasmacells)ormemoryBcells,whicharecrucialforsecondaryantigenencounter.CD19isalineage-differentiationMarker,asitsexpressionisdetectableattheearliestBcellstages,throughdevelopment,andisfinallylostupontransitiontomatureplasmacells.
TheHIB19antibodyiswidelyusedasaphenotypicmarkerforCD19expressiononBcells,aswellasondendriticcellsubsets.
| Name | PE-Cyanine5Anti-HumanCD19(HIB19) |
|---|---|
| Cat.No. | 55-0199 |
| AlternativeNames | Leu-12,B4 |
| GeneID | 930 |
| Clone | HIB19 |
| Isotype | MouseIgG1,kappa |
| Reactivity | Human |
| CrossReactivity | No |
| Format | PE-Cyanine5 |
| Applications | FlowCytometry |
| Citations* | KroenkeMA,EtoD,LocciM,ChoM,DavidsonT,HaddadEK,andCrottyS.2012.J.Immunol.188:3734-3744.(Flowcytometry) SoNSY,OstrowskiMA,andGray-OwenSD.2012.J.Immunol.188:4008-4022.(invitrocellcaptureformicroscopy) ZhangL,YangN,Conejo-GarciaJ-R,KatsarosD,Mohamed-HadleyA,FracchioliS,SchliengerK,TollA,LevineB,RubinSC,andCoukosG.2003.Clin.CancerRes.9:264–272.(Immunohistochemistry) HibeW,DirnhoferS,OberwasserlechnerF,EistererW,AmmanK,SchmidT,HilbeG,ThalerJ,andWollE.2003.J.Clin.Pathol.56:736-741.(Immunohistochemistry–frozentissues) |