企业QQ
官方微信
TheGARP5antibodyreactswithhumanGARP,alsoknownasLRRC32orGarpin,an80kDatransmembraneproteinwhichactsasareceptorforthelatentformofTGF-beta1(pro-TGF-beta),preventingitssecretion.Specifically,GARPisreportedtoassociatewiththepro-domainofTGF-beta1,knownaslatency-associatedpeptide(LAP),whichmustbecleavedtoreleasethebiologicallyactivecytokine.TheputativeroleofGARPinsequesteringtheTGF-betaisimportantforregulatingitsactivity,asTGF-betasignalingisinvolvedindevelopmentandfunctionofTh17,Tregandmanyotherimmunecelltypes.GARPexpressionhasbeenshownonplateletsandathighlevelsonFoxp3+Tregcells,whereitisproposedtobeaphenotypicidentifierforactivatedhumanTregcells.
TheGARP5antibodymaybeusedforanalysisofhumanGARPbyflowcytometry,immunoprecipitationandWesternblotting.Pleasechoosetheappropriateformatforeachapplication.
| Name | APCAnti-HumanGARP(GARP5) |
|---|---|
| Cat.No. | 20-9882 |
| AlternativeNames | LRRC32,Garpin |
| GeneID | 2615 |
| Clone | GARP5 |
| Isotype | MouseIgG1 |
| Reactivity | Human |
| CrossReactivity | |
| Format | APC |
| Applications | FlowCytometry |
| Citations* | WangI,ZhuJ,DongX,ShiM,LuC,andSpringerTA.2012.Mol.Biol.Cell.23:1129–1139.(Flowcytometry,Immunoprecipitation,Westernblot). |