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TheAFS98antibodyisspecificformouseCD115,alsoknownasColony-StimulatingFactor-1Receptor(CSF-1R),a145kDareceptorfromthePDGFreceptorfamily.ReceptoractivationbytheligandsIL-34orCSF-1(M-CSF)occursviahomodimerizationofCD115andsubsequenttyrosinephosphorylationandubiquitinationofintracellulardomains.CD115signalingpromotesdifferentiationofmyeloidprecursors,aswellasthecontinuedregulationofproliferation,survivalandfunctionofmononuclearphagocytes,dendriticcellsandosteoclasts.WhileIL-34andCSF-1mayinducesimilarcellularresponses,theyaredifferentiallyexpressedandassuchexertcomplimentaryactionsviaCD115.
TheAFS98antibodymaybeusedforidentificationofmyeloidlineagecellsbyflowcytometry,andiscommonlyusedforinvivoorinvitroneutralizationofCSF-1Receptor(useformatappropriateforfunctionalassays).
| Name | APCAnti-MouseCD115(c-fms)(AFS98) |
|---|---|
| Cat.No. | 20-1152 |
| AlternativeNames | CSF-1-R,FMS,Colony-StimulatingFactor1Receptor,M-CSFReceptor,CSF1R |
| GeneID | 12978 |
| Clone | AFS98 |
| Isotype | RatIgG2a,kappa |
| Reactivity | Mouse |
| CrossReactivity | |
| Format | APC |
| Applications | FlowCytometry |
| Citations* | GautierEL,ChowA,SpanbroekR,MarcelinG,GreterM,JakubzickC,BogunovicM,LeboeufM,vanRooijenN,HabenichtAJ,MeradM,andRandolphGJ.2012.J.Immunol.189:2614-2624.(Flowcytometry) NakamichiY,MizoguchiT,AraiA,KobayashiY,SatoM,PenningerJM,YasudaH,Kato,S,DeLucaHF,SudaT,UdagawaN,andTakahashiN.Proc.Natl.Acad.Sci.109:10006-10011.(invitroblocking) OkunoY,Nakamura-IshizuA,KishiK,SudaT,andKubotaY.2011.Blood.117:5264-5272.(invivoblocking) FixleyFJ,XiongY,YuRY-L,SahaiEA,StanleyER,andYeBH.2005.J.CellSci.118:1873-1883.(Westernblot) |