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TheICRF44antibodyreactswithhumanCD11b,alsoknownasintegrinalphaM.This165-170kDacellsurfaceglycoproteinispartofafamilyofintegrinreceptorsthatmediateadhesionbetweencells(cell-cell)andcomponentsoftheextracellularmatrix,e.g.fibrinogen(cell-matrix).Inaddition,integrinsareactivesignalingreceptorswhichrecruitleukocytestoinflammatorysitesandpromotecellactivation.Complete,functionalintegrinreceptorsconsistofdistinctcombinationsofintegrinchainswhicharedifferentiallyexpressed.IntegrinalphaM(CD11b)assembleswithIntegrinbeta-2(CD18)intoareceptorknownasMacrophageAntigen-1(Mac-1)orcomplementreceptortype3(CR3).ThisreceptorbindsandinducesintracellularsignalingthroughICAM-1,ICAM-2,ICAM-3andICAM-4onendothelialcellsandcanalsofacilitateremovalofiC3bbearingforeigncells.
TheICRF44antibodyiswidelyusedasaMarkerforCD11bexpressiononmacrophages,granulocytes,andsubsetsofNKcells.Itisreportedtobecross-reactivewithanumberofnon-humanspeciesincludingBaboon,Chimpanzee,Cynomolgus,RhesusandSwine.
| Name | APCAnti-HumanCD11b(ICRF44) |
|---|---|
| Cat.No. | 20-0118 |
| AlternativeNames | Mac-1,integrinαM,Itgam,CR3 |
| GeneID | 3684 |
| Clone | ICRF44 |
| Isotype | MouseIgG1,kappa |
| Reactivity | Human |
| CrossReactivity | Baboon,Chimpanzee,Cynomolgus,Rhesus,Swine |
| Format | APC |
| Applications | FlowCytometry |
| Citations* | FengC,ZhangL,AlmulkiL,FaezS,WhitfordM,Hafezi-MoghadamA,andCrossAS.2011.J.Leukoc.Biol.90:313-321.(Immunoprecipitation) ChangWLWandBarryPA.2010.Proc.Natl.Acad.Sci.107:22647-2652.(Flowcytometry–Rhesusmacaque) JerkeU,RolleS,DittmarG,BayatB,SantosoS,SporbertA,LuftF,andKettritzR.2010.J.Biol.Chem.286:7070-7081.(invitroblocking) MoreauA,HillM,ThebaultP,DeschampsJY,ChiffoleauE,ChauveauC,MoullierP,AnegonI,Alliot-LichtB,andCuturiMC.2009.FASEBJ.23:3070-3077.(Flowcytometry–cynomolgusmacaque) SengokuK,TakumaN,MiyamotoT,HorikawaM,andIshikawaM.2004.Hum.Reprod.19:639-644.(Immunofluorescencemicroscopy) DavidA,KacherY,SpecksU,andAviramI.2003.J.Leukoc.Biol.74:551-557.(Westernblot)RezzonicoR,ImbertV,ChicheporticheR,andDayerJ-M.2001.Blood.97:2932-2940.(invitroactivation) |