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TheEBVCS-5antibodyisspecificforhumanCD23,alsoknownasthelowaffinityIgEreceptor(FceRII),a45kDatypeIItransmembraneproteinandmemberoftheimmunoglobulinsuperfamily.ItisexpressedonmostBcellsandisupregulateduponactivation.ItisalsopresentonmantlezoneBcells,eosinophils,monocytesandasubsetofTcellsandplatelets.CD23playsaroleinBcelldevelopmentanddifferentiation,andalsofunctionstoregulateIgEproduction.SolublesecretedformsofCD23havebeenreportedtobindIgE,stimulatereleaseofpro-inflammatorycytokinesfrommonocytes,andplayaroleinBcelldifferentiation.
| Name | PEAnti-HumanCD23(EBVCS-5) |
|---|---|
| Cat.No. | 50-0237 |
| AlternativeNames | FcER2,FcεRII,LowaffinityimmunoglobulinepsilonFcreceptor,BLAST-2,Leu-20,B6 |
| GeneID | 2208 |
| Clone | EBVCS-5 |
| Isotype | MouseIgG1,kappa |
| Reactivity | Human |
| CrossReactivity | No |
| Format | PE |
| Applications | FlowCytometry |
| Citations* | KnappW,DorkenB,etal.eds.1989.LeucocyteTypingIV:WhiteCellDifferentiationAntigens.OxfordUniversityPress.NewYork. YukawaK,KikutaniH,OwakiH,YamasakiK,YokotaA,NakamuraH,BarsumianEL,HardyRR,SuemuraMandKishimotoT.1987.JImmunol.138(8):2576-2580. ArmantM,IshiharaH,RubioM,DelespesseGandSarfatiM.1994.JExpMed.1994.180(3):1005-1011. BelleauJT,GandhiRK,McPhersonHMandLewDB.2005.ClinMolAllergy.3:6.(Flowcytometry) FarrenTW,GiustinianiJ,LiuFT,TsitsikasDA,MaceyMG,CavenaghJD,OakerveeHE,TaussigD,NewlandAC,CalaminiciM,BensussanA,JennerM,GribbenJBandAgrawalSG.2011.Blood.118(8):2174-2183.(Flowcytometry) CromvikJ,JohnssonM,VahtK,JohanssonJEandWennerasC.2014.ImmunInflammDis.2(2):99-113.(Flowcytometry) |