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TheNOK-1antibodyreactswithhumanCD178(Fasligand)inbothmembraneboundandsolubleforms.Fasligandisa40kDatransmembraneglycoprotein,amemberoftheTNFfamily,andisexpressedbyactivatedTandNKcells,neutrophils,andmonocytes.InteractionsbetweenCD178(Fasligand)andCD95(Fas)induceaprogramofapoptosisandplayakeyroleinimmuneregulationandhomeostasis.TheextracellulardomainofhumanCD178canbecleavedfromthesurfacebymatrixmetalloproteinases(MMPs)resultingina26kDasolubleprotein.
| Name | APCAnti-HumanCD178(Fasligand)(NOK-1) |
|---|---|
| Cat.No. | 20-9919 |
| AlternativeNames | CD95L,Fasligand,FasL |
| GeneID | 356 |
| Clone | NOK-1 |
| Isotype | MouseIgG1,kappa |
| Reactivity | Human |
| CrossReactivity | No |
| Format | APC |
| Applications | FlowCytometry |
| Citations* | TanakaM,SudaT,TakahashiT,andNagataS.1995.EMBOJ.14(6):1129-1135. KayagakiN,KawasakiA,EbataT,OhmotoH,IkedaS,InoueS,YoshinoK,OkumuraK,andYagitaH.1995.JExpMed.182(6):1777-1783. SudaT,HashimotoH,TanakaM,OchiT,NagataS.1997.JExpMed.186(12):2045-2050. EhrenschwenderM,WajantH.2009.AdvExpMedBiol.647:64-93. |