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TheSJ25C1antibodyreactswithhumanCD19,a95kDaglycoproteinwhichactsasaco-receptor,alongwithCD21(CR2),CD81(TAPA-1)andCD225(Leu13),insupportofthefunctionalBcellreceptor(BCR).Thiscomplexprovidesantigen-specificrecognitionandsubsequentactivationofBcellstoproliferateanddifferentiateintoantibody-secretingcells(plasmacells)ormemoryBcells,whicharecrucialforsecondaryantigenencounter.Uponactivationandtyrosinephosphorylation,theCD19moleculecanprovideananchorforcytoplasmicsignalingproteinssuchasGRB2,SOSorPLCG2.CD19isalineage-differentiationMarker,asitsexpressionisdetectableattheearliestBcellstages,throughdevelopment,andisfinallylostupontransitiontomatureplasmacells.
TheSJ25C1antibodyiswidelyusedasaphenotypicmarkerforCD19expressiononBcells,aswellasondendriticcellsubsets.
| Name | PE-Cyanine5Anti-HumanCD19(SJ25C1) |
|---|---|
| Cat.No. | 55-0198 |
| AlternativeNames | Leu-12,B4 |
| GeneID | 930 |
| Clone | SJ25C1 |
| Isotype | MouseIgG1,kappa |
| Reactivity | Human |
| CrossReactivity | No |
| Format | PE-Cyanine5 |
| Applications | FlowCytometry |
| Citations* | PiatosaB,BirbachM,SiewieraK,UssowiczM,KalwakK,DrabkoK,RekawekA,TkaczykK,KurowskiPN.2013.CytometryPartB.84B:179–186.(FlowCytometry) SekiguchiDR,SmithSB,SutterJA,GoodmanNG,PropertK,LouzounY,RogersW,LuningPrakET.2011.CytometryPartB.80B:291–299.(FlowCytometry) DörkenB,MöllerP,PezzuttoA,Schwartz-AlbiezR,MoldenhauerG.B-cellantigens:CD19.In:KnappW,DörkenB,GilksWR,etal,ed.LeucocyteTypingIV:WhiteCellDifferentiationAntigens.NewYork,NY:OxfordUniversityPress;1989:34-36.(FlowCytometry) KarahanGE,EikmansM,AnholtsJDH,ClassFHJandHeidtS.2014.ClinExpImmunol.177(1):333-340.(FlowCytometry) BansalRR,MackayCR,MoserBandEbertM.2012.EurJImmunol.42(1):110-119.(FlowCytometry) JourdanM, CarauxA, CaronG, RobertN, FiolG, RèmeT, BolloréK, VendrellJP, LeGallouS, MourcinF, DeVosJ, KassambaraA, DuperrayC, HoseD, FestT, TarteKandKleinB.2011.JImmunol.187(8):3931-3941.(FlowCytometry) GovalJ-J,GreimersR,BoniverJanddeLevalL.2006.JHistochemCytochem.54(1):75-84.(Immunofluorescence–frozentissue) |