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The3.9antibodyreactswithhumanCD11c,alsoknownasintegrinalphaX.This150kDacellsurfaceglycoproteinispartofafamilyofintegrinreceptorsthatmediateadhesionbetweencells(cell-cell)andcomponentsoftheextracellularmatrix,e.g.fibrinogen(cell-matrix).Inaddition,integrinsareactivesignalingreceptorswhichrecruitleukocytestoinflammatorysitesandpromotecellactivation.Complete,functionalintegrinreceptorsconsistofdistinctcombinationsofintegrinchainswhicharedifferentiallyexpressed.IntegrinalphaX(CD11c)assembleswithIntegrinbeta-2(CD18)intoareceptorknownasCR4whichcanbindandinducesignalingthroughICAMsandVCAM-1onendothelialcellsandcanalsofacilitateremovalofiC3bbearingforeigncells.
The3.9antibodyiswidelyusedasaMarkerforCD11cexpressionondendriticcells(DC),ofteninparallelwithmarkersforCD11b,foridentificationofdevelopmentalstagesandmaturesubsetsofthiscelltype.CD11cisprominentlyexpressedontissuemacrophages,andisalsodetectedonactivatedneutrophils,granulocytes,sometypesofactivatedTcellsandintestinalintraepitheliallymphocytes(IEL).Theantibodyisreportedtobecross-reactivewithBaboon,Chimpanzee,CynomolgusandRhesusCD11c.
| Name | APC-Cyanine7Anti-HumanCD11c(3.9) |
|---|---|
| Cat.No. | 25-0116 |
| AlternativeNames | CR4,integrinalphaX,ITGAX |
| GeneID | 3687 |
| Clone | 3.9 |
| Isotype | MouseIgG1,kappa |
| Reactivity | Human |
| CrossReactivity | Baboon,Chimpanzee,Cynomolgus,Rhesus |
| Format | APC-Cyanine7 |
| Applications | FlowCytometry |
| Citations* | RobinsonBA,EstepRD,MessaoudiI,RogersKS,andWongSW.J.Virol.2012.86:2197-2211.(Flowcytometry–rhesusmacaque) Campillo-GimenezL,LaforgeM,FayM,BrusselA,et.al.2010.J.Virol.84(4):1838-1846.(Flowcytometry–Africangreenmonkey,rhesusmacaque) SadhuC,HendricksonL,DickKO,PotterTG,andStauntonDE.2008.J.ImmunoassayImmunochem.29(1):42-57.(invitroblocking) ArndtS,MelleC,MondalK,KleinG,vonEggelingF,andBosserhoffA-K.2007.J.Leukoc.Biol.82:1466-1472.(Immunoprecipitation) McGrealEP,IkewakiN,AkatsuH,MorganBP,andGasqueP.2002.168:5222-5232.(Immunofluorescencemicroscopy–frozentissue) |