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LKT/AXITINIB/A9435/25 mg

ProductIDA9435
CasNo.319460-85-0
Purity≥98%
  • Description
  • ProductInfo
  • ShippingandStorage
  • Downloads
  • References

Description

AxitinibisaninhibitorofVEGFRthatexhibitsanticancerchemotherapeuticandanti-angiogenicactivities.Axitinibiscurrentlyinclinicaltrialsasapotentialtreatmentforrenalcellcarcinoma.Invitro,axitinibincreaseslevelsofCD8+Tcellsanddecreaseslevelsofmyeloid-derivedsuppressorcells,inhibitingproliferationandincreasingapoptosis.Invivo,thiscompoundinhibitsexpressionofiNOS,arginase,IL-6,TNF-α,andIFN-γ,increasingapoptosisandinhibitingtumorgrowth.Inanimalmodelsoflungadenocarcinoma,axitinibdecreasestumorvasculatureandlesiongrowth.

ProductInfo

CasNo.

319460-85-0

Purity

≥98%

Formula

C22H18N4OS

FormulaWt.

386.47

ChemicalName

N-methyl-2-[[3-[(1E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl]sulfanyl]benzamide

IUPACName

N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]benzamide

MeltingPoint

213-224°C

Appearance

Whitetooffwhitepowder

ShippingandStorage

StoreTemp

Ambient

ShipTemp

Ambient

Downloads

InfoSheet

A9435InfoSheetPDF

References

ZhangX,FangX,GaoZ,etal.Axitinib,aselectiveinhibitorofvascularendothelialgrowthfactorreceptor,exertsananticancereffectinmelanomathroughpromotingantitumorimmunity.AnticancerDrugs.2014Feb;25(2):204-11.PMID:24135499.

Gross-GoupilM,FrançoisL,QuivyA,etal.Axitinib:AReviewofitsSafetyandEfficacyintheTreatmentofAdultswithAdvancedRenalCellCarcinoma.ClinMedInsightsOncol.2013Oct29;7:269-277.PMID:24250243.

MajetiBK,LeeJH,SimmonsBH,etal.VEGFisanimportantmediatoroftumorangiogenesisinmalignantlesionsinageneticallyengineeredmousemodeloflungadenocarcinoma.BMCCancer.2013Apr29;13(1):213.[Epubaheadofprint].PMID:23627488.

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