Granisetron is an antagonist at 5-HT3 receptors that exhibits antiemetic and anti-inflammatory activities. Unlike most similar-acting antiemetics, granisetron does not effect the cytochrome p450 metabolizing system. In animal models of colitis, this compound inhibited post-inflammatory visceral sensitivity.
| Cas No. | 107007-99-8 |
|---|---|
| Purity | ≥98% |
| Formula | C18H24N4O • HCl |
| Formula Wt. | 348.87 |
| Chemical Name | Endo-1-methyl-N-(9-methyl-9-aza bicyclo [3.3.1]non-3-yl)-1H-Indazole-3-carboxamide hydrochloride |
| IUPAC Name | 1-methyl-N-(9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)indazole-3-carboxamide;hydrochloride |
| Solubility | Soluble in water, DMSO, methanol, and ethanol. |
| Appearance | White or pale Yellow crystalline Powder |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| MSDS | G6802 MSDS PDF |
|---|---|
| Info Sheet | G6802 Info Sheet PDF |
Hsu ES. A review of granisetron, 5-hydroxytryptamine3 receptor antagonists, and other antiemetics. Am J Ther. 2010 Sep-Oct;17(5):476-86. PMID: 20844345.
Choi YD, Sung TS, Kim HJ, et al. Increased 5-hydroxytryptamine mediates post-inflammatory visceral hypersensitivity via the 5-hydroxytryptamine 3 receptor in rats. Dig Dis Sci. 2008 Nov;53(11):2909-16. PMID: 18357529.
Martin C, Roman V, Agay D, et al. Anti-emetic effect of ondansetron and granisetron after exposure to mixed neutron and gamma irradiation. Radiat Res. 1998 Jun;149(6):631-6. PMID: 9611102.
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