Desmopressinisasyntheticpeptidederivativeofargininevasopressinthatbindsandactivatesvasopressin-2receptors(V2Rs).Desmopressinexhibitspro-coagulant/pro-thromboticandantidiureticactivitiesandisclinicallyusedtotreatbleedingdisorderssuchashemophilia.Desmopressinenhancesplateletpro-coagulantactivityandincreaseplatelet-dependentthrombingenerationinaNa+/Ca2+-dependentmanner.
| CasNo. | 16679-58-6 |
|---|---|
| Purity | ≥95% |
| Formula | C46H64N14O12S2 |
| FormulaWt. | 1069.1 |
| ChemicalName | 1-(3-mercaptopropanoicacid)-8-D-argininevasopressin |
| IUPACName | N-[1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide |
| Synonym | Minirin;Desmospray;ADIuretinSD. |
| Appearance | Whitetooff-whitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | D1776InfoSheetPDF |
|---|
ColucciG,StutzM,RochatS,etal.Theeffectofdesmopressinonplateletfunction:aselectiveenhancementofprocoagulantCOAT-plateletsinpatientswithprimaryplateletfunctiondefects.Blood.2014Jan17.[Epubaheadofprint].PMID:24443440.
LeissingerC,CarcaoM,GillJC,etal.Desmopressin(DDAVP)inthemanagementofpatientswithcongenitalbleedingdisorders.Haemophilia.2014Mar;20(2):158-67.PMID:23937614.
JuulKV,KleinBM,SandströmR,etal.Genderdifferenceinantidiureticresponsetodesmopressin.AmJPhysiolRenalPhysiol.2011May;300(5):F1116-22.PMID:21367921.
SlusarzMJ,SlusarzR,CiarkowskiJ.InvestigationofmechanismofdesmopressinbindinginvasopressinV2receptorversusvasopressinV1aandoxytocinreceptors:moleculardynamicssimulationoftheagoNIST-boundstateinthemembrane-aqueoussystem.Biopolymers.2006Apr5;81(5):321-38.PMID:16333859.
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