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Xcessbio/Purmorphamine, Hedgehog Agonist -Xcessbio Biosciences Inc/5 mg solid/M66055-5s188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Xcessbio/Purmorphamine, Hedgehog Agonist -Xcessbio Biosciences Inc/5 mg solid/M66055-5s

Details
Product Information
Molecular Weight:520.62
Formula:C31H32N6O2
Purity:≥98%
CAS#: 483367-10-8
Solubility:DMSO up to 50 mM
Chemical Name:9-cyclohexyl-N-(4-morpholinophenyl)-2-(naphthalen-1-yloxy)-9H-purin-6-amine
Storage:Powder:4oC 1 year. DMSO:4oC3 month;-20oC 1 year.

Biological Activity:

Purmorphamine is a selective hedgehog pathway agonist that directly binds to and activates Smo receptor with an EC50 ~1 µM. It can promote the differentiation of both human and mouse mesenchymal progenitor cells into osteoblasts. In recent publications, purmorphamine was used as a patterning (ventralizing) molecule in differentiating human ESCs/iPSC into dopaminergic or motor neurons.

How to Use:

  • In vitro:Purmorphamine was used at 2-10 µM final concentration in cell culture.
  • In vivo: n/a

Reference:

  1. 1. Wu X, et al. A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells. (2002) J Am Chem Soc 124, 14520-14521.
  2. 2. Wu X, et al. Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway. (2004) Chem Biol 11 1229-1238.
  3. 3. Beloti MM, et al. Purmorphamine enhances osteogenic activity of human osteoblasts derived from bone marrow mesenchymal cells. (2005) Cell Biol Int 29(7) 537-541.
  4. 4. Sinha S, et al. Purmorphamine activates the hedgehog pathway by targeting smoothened. (2006) Nat Chem Biol 2(1) 29-30.
  5. 5. Kriks S, et al. Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease. (2011) Nature 480, 547–551.
  • purmorphamine_spec.pdf
  • purmorphamine_MSDS.pdf

Products are for research use only. Not for human use.

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