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Xcessbio/Bromosporine, Pan-bromodomain Inhibitor-Xcessbio Biosciences Inc/10 mM in DMSO (0.494 mL)/M60144-2188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Xcessbio/Bromosporine, Pan-bromodomain Inhibitor-Xcessbio Biosciences Inc/10 mM in DMSO (0.494 mL)/M60144-2

Details
Product Information
Molecular Weight:404.44
Formula:C17H20N6O4S
Purity:≥98%
CAS#:n/a
Solubility:DMSO up to 100 mM
Chemical Name:ethyl (3-methyl-6-(4-methyl-3-(methylsulfonamido)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-8-yl)carbamate
Storage:Powder:4oC 1 year. DMSO:4oC3 month;-20oC 1 year.

Biological Activity:

Bromosporine is a broad spectrum inhibitor for bromodomains with IC50of 0.41 μM, 0.29 μM, 0.122 μM and 0.017 μM for BRD2, BRD4, BRD9 and CECR2, respectively. In cell-based assays, Bromosporine (1 µM) accelerates FRAP recovery of BRD4 and CREBBP, while shows no activities against TIF1α, BAZ2A, and SMARCA2 (at 10 µM). Bromosporine shows moderate cytotoxicity in HeLa cells at 18 µM. It is a very useful chemical probe for bromodomain functional assays.

How to Use:

In vitro: Bromosporine was used at 1 µM final concentration in vitro and in cellular assays.

In vivo:n/a

Reference:

  1. 1. http://www.thesgc.org/
bromosporine_spec.pdf
bromosporine_MSDS.pdf
Products are for research use only. Not for human use.

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