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Xcessbio/BAF312, S1P1/5 Selective Agonist-Xcessbio Biosciences Inc/2 mg solid/M60039-2s188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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产品资料

Xcessbio/BAF312, S1P1/5 Selective Agonist-Xcessbio Biosciences Inc/2 mg solid/M60039-2s

Details
ProductInformation
ChemicalName:(E)-1-(4-(1-(((4-cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)azetidine-3-carboxylicacid
MolecularWeight:516.60
Formula:C29H35F3N2O3
Purity:≥98%
CAS#:800379-64-0
Solubility:DMSOupto100mM
Storage:Powder:4oC1yearDMSO:4oC3month-20oC1year

BIOLOGicalActivity:

BAF312isanext-generationpotentsphingosine1-phosphate(S1P)receptoragoNIST,selectiveforS1P1(EC50~0.39nM)andS1P5(EC50~0.98nM).AsS1P1playsacentralroleinlymphocyteegressfromlymphnodesandisavalidateddrugtargetinimmune-mediateddiseases,BAF312iscurrentlyinclinicaltrialstotreatmultiplesclerosis.

HowtoUse:

Invitro:BAF312wasusedat0.1µMinvitro.

Invivo:BAF312wasorallydosedoncedailyat0.3-3mg/kginchronicEAE,DAratsandwasshowngoodefficacy.

Reference:

  1. 1.GergelyP,etal.TheselectiveS1PreceptormodulatorBAF312redirectslymphocytedistributionandhasspecies-specificeffectsonheartrate:translationfrompreclinicaltoclinicalstudies.(2012)BrJPharmacol.167(5):1035-47.
  2. 2.PanSF,etal.DiscoveryofBAF312(Siponimod),aPotentandSelectiveS1PReceptorModulator.(2013)ACSMed.Chem.Lett.Inpress.
  3. 3.FryerRM,etal.Theclinically-testedS1Preceptoragonists,FTY720andBAF312,demonstratesubtype-specificbradycardia(S1P₁)andhypertension(S1P₃)inrat.(2012)PLoSOne.(12):e52985.

BAF312_spec.pdf

BAF312_MSDS.pdf

Productsareforresearchuseonly.Notforhumanuse.

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