ChemicalName: | (E)-1-(4-(1-(((4-cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)azetidine-3-carboxylicacid |
MolecularWeight: | 516.60 |
Formula: | C29H35F3N2O3 |
Purity: | ≥98% |
CAS#: | 800379-64-0 |
Solubility: | DMSOupto100mM |
Storage: | Powder:4oC1yearDMSO:4oC3month-20oC1year |
BAF312isanext-generationpotentsphingosine1-phosphate(S1P)receptoragoNIST,selectiveforS1P1(EC50~0.39nM)andS1P5(EC50~0.98nM).AsS1P1playsacentralroleinlymphocyteegressfromlymphnodesandisavalidateddrugtargetinimmune-mediateddiseases,BAF312iscurrentlyinclinicaltrialstotreatmultiplesclerosis.
HowtoUse:
Invitro:BAF312wasusedat0.1µMinvitro.
Invivo:BAF312wasorallydosedoncedailyat0.3-3mg/kginchronicEAE,DAratsandwasshowngoodefficacy.
Reference:
BAF312_spec.pdf
BAF312_MSDS.pdf
Productsareforresearchuseonly.Notforhumanuse.
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