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Xcessbio/Daidzein-2c, Osteogenic Modulator-Xcessbio Biosciences Inc/2mg solid/M60158-2s188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Xcessbio/Daidzein-2c, Osteogenic Modulator-Xcessbio Biosciences Inc/2mg solid/M60158-2s

Details
ProductInformation
MolecularWeight:296.32
Formula:C18H16O4
Purity:≥98%
CAS#:97846-18-9
Solubility:DMSOupto100mM
ChemicalName:3-(4-hydroxyphenyl)-7-isopropoxy-4H-chromen-4-one
Storage:Powder:4oC1year.DMSO:4oC3month;-20oC1year.

BIOLOGicalActivity:

Daidzein-2cisapotentsyntheticdaidzeinanalog,hasosteogenicinductionpotentialsonhumanMesenchymalStemCells(MSC).HumanbonemarrowderivedmesenchymalstemcellsfromthreedifferentdonorsweretreatedwithDaidzein-2candshowntoexhibitenhancedosteogenesiswhencomparedtodaidzeinorestrogentreatment.TheenhancedosteogenicinductionbyDaidzein-2cresultedinincreasedosterix(Sp7),alkalinephosphatase(ALP),osteopontin(OPN),andinsulin-likegrowthfactor1(IGF-1),whichareosteogenicfactorsthatregulatethematurationofosteogenicProgenitorcellsintomoredifferentiatedosteoblastcells.Itservesasausefulchemicaltooltofurthervalidateanddevelopnoveltreatmentsofosteoporosisviapromotingboneformation.

HowtoUse:

  • Invitro:Daidzein-2cwasusedat1µMfinalconcentrationinvariousinvitroassays.
  • Invivo:N/A

Reference:

  • 1.AmyL,etal.Design,Synthesis,andOsteogenicActivityofDaidzeinAnalogsonHumanMesenchymalStemCells.(2014)ACSMed.Chem.Lett.,Inpress.

  • Daidzein-2c_spec.pdf
  • Daidzein-2c_MSDS.pdf

Productsareforresearchuseonly.Notforhumanuse.

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