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Xcessbio/IWP-2, Porcupine (Wnt) Inhibitor -Xcessbio Biosciences Inc/2mg solid/M60115-2s188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Xcessbio/IWP-2, Porcupine (Wnt) Inhibitor -Xcessbio Biosciences Inc/2mg solid/M60115-2s

Details
Product Information
Molecular Weight:466.60
Formula:C22H18N4O2S3
Purity:≥98%
CAS#:686770-61-6
Solubility:DMSO up to 10 mM
Chemical Name: N-(6-methylbenzo[d]thiazol-2-yl)-2-((4-oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)acetamide
Storage:Powder:4oC 1 year. DMSO:4oC3 month;-20oC 1 year.

Biological Activity:

IWP-2 is a potent and highly selective Wnt signaling antagonist with an IC50~ 27 nM in the L-Wnt-STF cellular assay. It prevents palmitoylation of Wnt proteins by Porcupine (a membrane-bound O-acyltransferase), thereby blocking Wnt protein secretion and activity. It blocks Wnt-dependent phosphorylation of Lrp6 receptor and Dvl2, and β-catenin accumulation. IWP-2 is a useful chemical probe in both regenerative medicine and anticancer efforts.

How to Use:

  • In vitro:IWP-2 was used at 1-2 µM in vitro and in cellular assays.
  • In vivo:n/a

Reference:

  • 1. Chen B, et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. (2009) Nat Chem Biol. 5(2):100-7.
  • 2. ten Berge D, et al. Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells. (2011) Nat Cell Biol. 13(9):1070-5.
  • 3. Lian X, et al. Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. (2012) Proc Natl Acad Sci USA. 109(27):E1848-57.

  • IWP-2_spec.pdf
  • IWP-2_MSDS.pdf

Products are for research use only. Not for human use.

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