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| Chemical Name: | 2-(7-chloro-4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)-3-(2,4-dichlorophenyl)-3-oxopropanenitrile |
| Molecular Weight: | 392.62 |
| Formula: | C17H8Cl3N3O2 |
| Purity: | ≥98% |
| CAS#: | 1370554-01-0 |
| Solubility: | DMSO up to 25 mM |
| Storage: | Powder:4oC 1 year DMSO:4oC3 month-20oC 1 year |
Ciliobrevin D is the first specific small molecule antagonist of cytoplasmic dynein, and can inhibit both cytoplasmic dynein 1 and 2. The conversion of chemical energy into mechanical force by AAA+ ATPases is integral to cellular processes, including DNA replication, protein unfolding, cargo transport and membrane fusion. The AAA+ ATPase motor cytoplasmic dynein regulates ciliary trafficking, mitotic spindle formation and organelle transport. Ciliobrevin D perturbs protein trafficking within the primary cilium, leading to their malformation and Hedgehog signaling blockade. It also prevents spindle pole focusing, kinetochore–microtubule attachment, melanosome aggregation and peroxisomemotility in cultured cells. Ciliobrevin D can block dynein-dependent microtubule gliding and ATPase activity in vitro. Therefore it serves as a useful probe for dynein-dependent processes and studying cellular processes that require this microtubule motor.
How to Use:
Reference:
Cilliobrevin_D_spec.pdfCilliobrevin_D_MSDS.pdfProducts are for research use only. Not for human use.
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