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Xcessbio/RA190, Ubiquitin Receptor RPN13/ADRM1 Inhibitor-Xcessbio Biosciences Inc/10 mM in DMSO (0.357 mL)/M60163-2188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Xcessbio/RA190, Ubiquitin Receptor RPN13/ADRM1 Inhibitor-Xcessbio Biosciences Inc/10 mM in DMSO (0.357 mL)/M60163-2

Details
ProductInformation
MolecularWeight:560.30
Formula:C28H22Cl4N2O2
Purity:≥98%
CAS#:n/a
Solubility:DMSOupto50mM
ChemicalName:(3E,5E)-1-((S)-2-amino-3-phenylpropanoyl)-3,5-bis(3,4-dichlorobenzylidene)piperidin-4-one
Storage:Powder:4oC1year.DMSO:4oC3month;-20oC1year.

BIOLOGicalActivity:

RA190isanovelpotentandselectiveinhibitorofproteasomeUbiquitinreceptorRPN13/ADRM1.Itcovalentlybindstothecysteine88ofubiquitinreceptorRPN13inthe19Sregulatoryparticleandinhibitsproteasomefunction,triggeringrapidaccumulationofpolyubiquitinatedproteins.Multiplemyeloma(MM)lines,eventhoseresistanttobortezomib,weresensitivetoRA190viaendoplasmicreticulumstress-relatedapoptosis.RA190stABIlizedtargetsofhumanpapillomavirus(HPV)E6oncoprotein,andpreferentiallykilledHPV-transformedcells.Afteroralorintraperitonealdosinginmice,RA190distributedtoplasmaandmajororgansexceptthebrain,andinhibitedproteasomefunctioninskinandmuscle.RA190admiNISTrationprofoundlyreducedgrowthofMMandovariancancerxenografts,andoralRA190treatmentretardedHPV16(+)syngeneicmousetumorgrowth,withoutaffectingspontaneousHPV-specificCD8(+)Tcellresponses,suggestingitstherapeuticpotential.

HowtoUse:

  • Invitro:RA190wasusedat1-10µMfinalconcentrationinvariousinvitroassays.
  • Invivo:RA190wasadministeredbyintraperitonealinjectiononceadayatadoseof20mg/kgintumormodels.

Reference:

  • 1.AnchooriRK,etal.Abis-BenzylidinePiperidoneTargetingProteasomeUbiquitinReceptorRPN13/ADRM1asaTherapyforCancer.(2013)CancerCell.24(6):791-805.
  • RA190_spec.pdf
  • RA190_MSDS.pdf
Productsareforresearchuseonly.Notforhumanuse.

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