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Xcessbio/BRD9757, HDAC6 Inhibitor-Xcessbio Biosciences Inc/2 mg solid/M60117-2s188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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产品资料

Xcessbio/BRD9757, HDAC6 Inhibitor-Xcessbio Biosciences Inc/2 mg solid/M60117-2s

Details
ProductInformation
MolecularWeight:127.14
Formula:C6H9NO2
Purity:≥98%
CAS#:1423058-85-8
Solubility:DMSOupto100mM
ChemicalName:N-hydroxycyclopent-1-enecarboxamide
Storage:Powder:4oC1year.DMSO:4oC3month;-20oC1year.

BIOLOGicalActivity:

BRD9757isahighlypotentandselectiveHDAC6inhibitorwithanIC50of30nMtowardHDAC6.Ithas>20-foldselectivityforclassIand>400-foldselectivityforclassIIHDACstested.BRD9757isabsenceofasurface-bindingmotif.ItdemonstratesthathighselectivityandpotentinhibitionofHDAC6canbeachievedthroughcarefulchoiceoflinkerelementonly.BRD9757canbeusedasausefultoolforprobingthebiologicalfunctionsandrelevanceofthedifferentHDACisoforms,andservesasabasisfornewselectiveinhibitorsofotherHDACisoforms.

HowtoUse:

Invitro:BRD9757wassuggestedtobeusedat10µMfinalconcentrationinvitroandincellularassays.

Invivo:n/a

Reference:

  1. 1.WagnerFF,etal.PotentandSelectiveInhibitionofHistoneDeacetylase6(HDAC6)DoesNotRequireaSurface-BindingMotif.(2013)JMedChem.56(4),1772–1776.

BRD9757_spec.pdf

BRD9757_MSDS.pdf

Productsareforresearchuseonly.Notforhumanuse.

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