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Bpsbioscience/A-966492/27601-1/5 mg

MW:324.4Da
CASRegistry#:934162-61-5
Formula:C18H17FN4O
Target:PARP1,PARP2
Background:
A-966492isoneofthemostpotentPARPinhibitors.A-966492displaysexcellentpotencyagainstthePARP-1enzymewithaKiof1nMandanEC50of1nMinawholecellassay.A-966492significantlyenhancestheefficacyofTMZinadose-dependentmanner.Inaddition,A-966492isorallybioavailableacrossmultiplespecies,crossestheblood?brainbarrier,andappearstodistributeintotumortissue.A-966492representsapromising,structurallydiversebenzimidazoleanalogueandisbeingfurthercharacterizedpreclinically.
Description:
A-966492isanovelandpotentinhibitorofPARP1andPARP2withKiof1nMand1.5nM,respectively.
Synonym(s):
2-[2-fluoro-4-[(2S)-pyrrolidin-2-yl]phenyl]-1H-benzimidazole-4-carboxamide
Purity:

≥98%byHPLC

Solubility:
SolubleinDMSO65mg/ml,Water<1mg/ml,Ethanol<1mg/ml
Storage/StABIlity:

Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.

Reference(s):
PenningTD,etal.JMedChem.2010Apr22;53(8):3142-53.
ScientificCategory:
PARPInhibitor
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
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