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Bpsbioscience/Thalidomide/27721-1/200 mg

MW:258.2Da
CASRegistry#:50-35-1
Formula:C13H10N2O4
Description:
Thalidomideisateratogen,sedative-hypnoticwithinherentanti-inflammatoryproperties.Aselectiveinhibitoroftumornecrosisfactorβ(TNF-β)synthesis.BindstotheE3ubiquitinligasecomplexformedbetweencereblon(CRBN),damagedDNAbindingprotein1(DDB1),andCul4Ainhibitingligaseactivity.InhibitsFGF-inducedangiogenesis.ThalidomideinitiatesitsteratogeniceffectsbybindingtoCRBNandinhibitingtheassociatedubiquitinE3ligaseactivity.Cellpermeable.
Synonym(s):
N–(2,6–dioxo–3–piperidinyl)phthalimide
Purity:
>98%byTLC.
Solubility:
SolubleinDMSO(25mg/ml)
Format:
Whitepowder
Storage/StABIlity:

Storeat+4°C.Stableassuppliedforupto2yearswhenstoreddessicatedat+4°C.Storesolutionsat-20°Cforupto2months.

Application(s):
UsefulforinhibitionofE3ubiquitinligaseenzymes
Reference(s):
1.ItoTetal.Teratogeniceffectsofthalidomide:molecularmechanisms.CellMolLifeSci.2011May;68(9):1569-79.
2.ItoTetal.IdentificationofaPrimaryTargetofThalidomideTeratogenicity.Science,2010.327(5971):1345-1350.
Warning(s):
Caution:Teratogen.Protectfrommoisture.
ScientificCategory:
UbiquitinEnzymes
ProductType:
Inhibitors/Activators
Datashownislot-specific.Contactusforspecificinformationonotherlots.
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