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Wehaveappliedourinnovativetechnologytodevelophumanneuralstemcellsdirectlydifferentiatedfrom Huntington’sDiseaseiPScells. OurcellsallowHuntington"sDiseaseresearcherstobuildtheirownhumancellularmodelsinadisease-relevantgeneticandtissuecontext.
Ourready-to-usekitsallowyoutoconcentrateonyourexperimentsratherthanspendingvaluabletimeandresourcesgeneratingHuntington"sDiseaseneuralProgenitorsin-house. Aspartofthe HDNSCkit,youwillreceive Plating-XFMedium inadditiontoyourvialofhumanneuralstemcellstomaximizecellviABIlity.
HDNSCs arereadymadeandeasytodifferentiate. Theyarecapableofdifferentiatingintoaspectrumofcorticalexcitatoryandinhibitoryneuronsandremainviableincultureformonths,facilitatingreproducIBLeandlong-termstudies.
WhetheryouwanttostudyHuntington"sDiseasepathogenesisatthecellularlevel,performneurotoxicitytestingorpre-clinicaldrugscreening,webelievethat HDNSCs,alongsideouroptimized culturereagents,providetheperfectculturesystemforyourresearchsuccess.
TheimagewastakenatDay7invitro.InthecentreoftheimageyoucanseeHDNSCsinaneuralrosetteformation.Neuriteoutgrowthcanalsobeobserved.
HDNSCswerefixedafter7daysincultureandstainedusingourimmunocytochemistyprotocol.TheneuralstemcellswerecounterstainedwithDAPItovisualisethenuclei.Thecellscanbeseentoexpressneuralstem/progenitorcellmarkersKi67,NestinandPax6.
DAPI Pax6 Nestin
DAPINestinKi67
HumancellsderivedfromdiagnosedHuntington"sDiseasepatients
Availableinindustrialquantity
Highpurityneuralstemcellpopulation
Ready-madeandeasytodifferentiate
Robustenoughtoundergogeneticmanipulation
Capableofdifferentiatingtoaspectrumofcorticalexcitatoryandinhibitoryneurons
Remainviableincultureformonthstofacilitatereproducibleandlongtermstudies
StudyingHuntington"sDiseasepathogenesisatthecellularlevel
StudyingneuralnetworkformationandsignaltransmissioninHuntington"sDiseaseneuralculture
Neurotoxicitytesting
Preclinicaldrugefficacytesting
Co-culturestudieswithastrocytes
| Startingmaterial | Fibroblasts |
| Donorgender | Female |
| Donorageatsampling | 48yrs |
| Donorageofonset | 42yrs |
| Reprogrammingmethod | Retroviral |
| Inductionmethod | Monolayer&chemicallydefinedmedium |
| Size | ≥1.5millioncells |
| Kitcomponents | 1vialofNeuralStemCells(≥1.5millioncells)and1bottleofNeuralPlating-XFMedium(30mL) |
| Celltype | iPSC-derivedneuralstemcells |
| Growthproperties | Adherent |
| Shippingconditions | Dryice |
| Storageconditions | Liquidnitrogen |
matriks/Shikari® (S-ATP) Anti-Pembrolizumab ELISA w/confirmation/PEM-QNS-KEY
intactgenomics/Methionine Auxotrophic LBA4404 | ig® | Intact Genomics/15x50μl/1076-15
goprolytix/Proteolytic Activation of Prothrombin/1 mg, 200 µg/BCT-DFP
novateinbio/Dynorphin A ( 13-17 ) Porcine Peptide/5mg/PE-54024_5mg
matriks/Shikari® (Q-ETA) Etanercept ELISA/ETA-FD-ENB
intactgenomics/Agrobacterium ElectroComponent Combo Pack | Intact Genomics/12x50µl/1290-24
Jackson/Peroxidase AffiniPure Goat Anti-Mouse IgG (H+L)/2.0 ml/115-035-003
Jackson/Peroxidase AffiniPure Goat Anti-Rabbit IgG (H+L)/2.0 ml/111-035-003
Qubit™ dsDNA BR Assay Kit Q32853现货
Invitrogen Q32855 Qubit™ RNA HS Assay Kit现货促销
LUCK-1G,D-Luciferin, Potassium Salt 钾盐现货
GoldBio/D-Luciferin, Sodium Salt (Proven and Published™)/LUCNA-1G/1 g