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Adipogen/CD279 [PD-1] (human) (rec.)/CHI-HF-200PD1-C050/50 µg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Adipogen/CD279 [PD-1] (human) (rec.)/CHI-HF-200PD1-C050/50 µg

MoreInformation
ProductDetails
SynonymsPD-1;ProgrammedCellDeathProtein1
ProductTypeProtein
Properties
Source/HostHEK293cells
SequenceTheextracellulardomainofhumanCD279[PD-1](aa25-167)isuntagged.
CrossreactivityHuman
BIOLOGicalActivityMeasuredbyitsbindingABIlityinafunctionalELISA.
MW~30kDa(SDS-PAGE)
Purity≥95%(SDS-PAGE)
EndotoxinContent<0.01eu mu;g="" protein="" (lal="" test;="" lonza).="">
ReconstitutionReconstitute50µgvialwith100µlsterilewatertoaconcentrationof0.5mg/ml.
Add1XPBStothedesiredproteinconcentration.
FormulationLyophilizedfrom0.2μm-filteredsolutioninPBS.
OtherProductDataNCBIreferenceNP_005009.2:CD279(human)
DeclarationManufacturedbyChimerigen.
ShippingandHandling
ShippingBLUEICE
ShortTermStorage+4°C
LongTermStorage-20°C
HandlingAdviceAvoidfreeze/thawcycles.
PBScontainingatleast0.1%BSAshouldbeusedforfurtherdilutions.
Use/StabilityStableforatleast1yearafterreceiptwhenstoredat-20°C.
Workingaliquotsarestableforupto3monthswhenstoredat-20°C.
Documents
MSDSNo
ProductSpecificationSheet
DatasheetDownloadPDF
CD279(ProgrammedCellDeathProtein1;PD-1)isatypeItransmembraneproteinbelongingtotheCD28/CTLA-4familyofimmunoreceptorsthatmediatesignalsforregulatingimmuneresponses.MembersoftheCD28/CTLA-4familyhavebeenshowntoeitherpromoteTcellactivation(CD28andICOS)ordownregulateTcellactivation(CTLA-4andPD-1).CD279isexpressedonactivatedTcells,Bcells,myeloidcellsandonasubsetofthymocytes.Invitro,ligationofCD279inhibitsTCR-mediatedTcellproliferationandproductionofIL-1,IL-4,IL-10andIFN-γ.Inaddition,CD279ligationalsoinhibitsBCRmediatedsignaling.CD279deficientmicehaveadefectinperipheraltoleranceandspontaneouslydevelopautoimmunediseases.
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