Rockland/AntiHuman IL17A (MOUSE) Biotin Conjugated Antibody/209306B32/100 µg

Anti-HumanIL-17A(MOUSE)BiotinConjugatedAntibodyProperties

Description

Anti-HumanIL-17A(MOUSE)BiotinConjugatedMonoclonalAntibody-209-306-B32

Host

Mouse

TargetSpecies

Human

KnownCrossReactivity

human

Clonality

Monoclonal4H1524.1IgG2b

Application

ELISA:1:10,000-1:50,000
FlowCytometry:UserOptimized
WesternBlot:1µg/mL
OtherDilution:UserOptimized

PhysicalState

Lyophilized

ShippingCondition

Ambient

Format

IgG2b

Label

Biotin

FPValue

10-20molesBiotinpermoleofIgG2b

Concentration

1.0mg/mLbyUVabsorbanceat280nm

Buffer

0.02MPotassiumPhosphate,0.15MSodiumChloride,pH7.2

ReconstitutionVolume

100µL

ReconstitutionBuffer

Restorewithdeionizedwater(orequivalent)

Preservative

0.01%(w/v)SodiumAzide

StABIlizer

10mg/mLBovineSerumAlbumin(BSA)-ImmunoglobulinandProteasefree

GeneName

IL17A

RelevantLinks

UniProtKB-Q16552
GeneID-3605
NCBI-NP_002181.1

Anti-HumanIL-17A(MOUSE)BiotinConjugatedAntibodyDescription

Background

IL17-A(alsoknownasInterleukin-17)isaproinflammatorycytokineproducedbyactivatedTcells.ThiscytokineregulatestheactivitiesofNF-kappaBandmitogen-activatedproteinkinases.ThiscytokinecanstimulatetheexpressionofIL6andcyclooxygenase-2(PTGS2/COX-2),aswellasenhancetheproductionofnitricoxide(NO).Highlevelsofthiscytokineareassociatedwithseveralchronicinflammatorydiseasesincludingrheumatoidarthritis,psoriasisandmultiplesclerosis.IL17-AisthefoundingmemberofagroupofcytokinescalledtheIL17family.IL17-AwasoriginallyidentifiedasatranscriptfromarodentT-cellhybridoma.Toelicititsfunctions,IL17bindstoatypeIcellsurfacereceptorcalledIL17RofwhichthereareatleastthreevariantsIL17RA,IL17RB,andIL17RC.Anti-IL-17AantibodyisidealforinvestigatorsinvolvedinImmunologyresearch.

Synonyms

mouseanti-Interleukin-17Abiotinconjugatedantibody,mouseanti-IL-17Abiotinconjugatedantibody,IL-17A,Interleukin-17A,CytotoxicT-Lymphocyte-associatedAntigen8,CTLA8,Interleukin-17,IL17,IL-17,Interleukin17

Immunogen

Anti-IL-17A(MOUSE)MonoclonalAntibodywasproducedinmousebyrepeatedimmunizationswithmaturefulllengthrecombinanthumanIL-17AproducedinE.colifollowedbyhybridomadevelopment.

ImmunogenType

RecombinantProtein

StorageCondition

Storevialat4°Cpriortorestoration. Restorewith0.1mLofdeionizedwater(orequivalent).Forextendedstoragealiquotcontentsandfreezeat-20°Corbelow. Avoidcyclesoffreezingandthawing. Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature. Thisproductisstableforseveralweeksat4°Casanundilutedliquid. Diluteonlypriortoimmediateuse.

ApplicationNote

ThispurifiedantibodyhasbeentestedforuseinFLOWandWesternBlot.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.

Purity/Specifity

ThisproductwaspurifiedfromconcentratedtissueculturesupernatebyProteinGchromatographyfollowedbyextensivedialysisagainstthebufferstatedabove.ThisantibodyisspecificforhumanIL-17Aprotein.ABLASTanalysiswasusedtosuggestcross-reactivitywithIL-17Afromhumansourcesbasedon100%homologywiththeimmunizingsequence.Cross-reactivitywithIL-17Afromothersourceshasnotbeendetermined.

DisclaimerNote-General

Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.

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Rockland/AntiHuman IL17A (MOUSE) Biotin Conjugated Antibody/209306B32/100 µg

Anti-HumanIL-17A(MOUSE)BiotinConjugatedAntibodyProperties

Anti-HumanIL-17A(MOUSE)BiotinConjugatedAntibodyDescription