Rockland/ABCB1 Antibody/600401967/100 µg

ABCB1AntibodyProperties

Description

Anti-ABCB1(RABBIT)Antibody-600-401-967

Host

Rabbit

TargetSpecies

Human

KnownCrossReactivity

human,monkey,dog,mouse,rat

Clonality

Polyclonal

Application

ELISA:1:10,000-1:50,000
WesternBlot:1:200-1:2,000
Immunohistochemistry:UserOptimized
OtherDilution:UserOptimized

PhysicalState

Liquid(sterilefiltered)

ShippingCondition

DryIce

Format

IgG

Label

Unconjugated

Concentration

1.0mg/mLbyUVabsorbanceat280nm

Buffer

0.02MPotassiumPhosphate,0.15MSodiumChloride,pH7.2

Preservative

0.01%(w/v)SodiumAzide

Stabilizer

None

GeneName

ABCB1

RelevantLinks

GeneID-5243
NCBI-42741659
UniProtKB-P08183

ABCB1AntibodyDescription

Background

Thisantibodyisdesigned,produced,andvalidatedaspartofacollaborationbetweenRocklandandtheNationalCancerInstitute(NCI)andissuitableforCancer,ImmunologyandNuclearSignalingresearch.ATP-BindingCassetteSub-FamilyBMember1(ABCB1,alsonamedP-glycoprotein)isaplasmamembrane-associatedmultidrugtransporterthatutilizestheenergyofATPhydrolysistopumptoxicxenobioticsoutofcells.UniquefeaturesofABCB1areitsverybroadsubstratespecificityanditsbasalATPaseactivityintheabsenceoftransportsubstrates.HumanABCB1playsanimportantroleinabsorption,distribution,metabolism,excretionandtoxicityofpharmacologicallyrelevantdrugs.Itisresponsiblefordecreaseddrugaccumulationinmultidrug-resistantcellsandoftenmediatesthedevelopmentofresistancetoanti-cancerdrugs.Thisproteinalsofunctionsasatransporteracrosstheblood-brainbarrier.

Synonyms

rabbitanti-ABCB1Antibody,ABCB1,ABCB-1,ATPbindingcassettesubfamilyBMDR/TAPmember1antibody,CD243antibody,CD243antigenantibody,CLCSantibody,GP170antibody,MDR1antibody

Immunogen

Thisaffinitypurifiedantibodywaspreparedfromwholerabbitserumproducedbyrepeatedimmunizationswithasyntheticpeptidecorrespondingtoaminoacids262-277ofhumanABCB1protein.

ImmunogenType

Peptide

StorageCondition

Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.

ApplicationNote

ThisaffinitypurifiedantibodyhasbeentestedforuseinELISAandwesternblot.

Purity/Specifity

Thisaffinity-purifiedantibodyisdirectedagainsthumanABCB1protein.Theproductwasaffinitypurifiedfrommonospecificantiserumbyimmunoaffinitychromatography. ABLASTanalysiswasusedtosuggestcrossreactivitywithABCB1proteinfromhuman,monkey,dog,mouse,andratbasedon100%homologywiththeimmunizingsequence. Reactivityagainsthomologuesfromothersourcesisnotknown.

DisclaimerNote-General

Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.Theprospectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.

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Rockland/ABCB1 Antibody/600401967/100 µg

ABCB1AntibodyProperties

ABCB1AntibodyDescription