Rockland/AR Phospho pY267 Antibody/600401J95/50 µg

ARPhosphopY267AntibodyProperties

Description

Anti-AndrogenReceptorpY267(RABBIT)Antibody-600-401-J95

Host

Rabbit

TargetSpecies

Human

KnownCrossReactivity

human

Clonality

Polyclonal

Application

ELISA:1:10,000
WesternBlot:1ug/ml

PhysicalState

Liquid(sterilefiltered)

ShippingCondition

DryIce

Format

IgG

Label

Unconjugated

Concentration

1.1mg/mLbyUVabsorbanceat280nm

Buffer

0.02MPotassiumPhosphate,0.15MSodiumChloride,pH7.2

Stabilizer

30%Glycerol

GeneName

RelevantLinks

UniProtKB-P10275

ARPhosphopY267AntibodyDescription

Background

AndrogenReceptordetectshumanAndrogenreceptor.Theandrogenreceptor(AR)isan~110kDaandrogen-dependenttranscriptionfactorthatisamemberofthesteroid/nuclearreceptorgenesuperfamily.TheARsignalingpathwayplaysakeyroleindevelopmentandfunctionofmalereproductiveorgans,includingtheprostateandepididymis.ARalsoplaysaroleinnonreproductiveorgans,suchasmuscle,hairfollicles,andbrain.AbnormalitiesintheARsignalingpathwayhavebeenlinkedtoanumberofdiseases,includingprostatecancer,Kennedysdiseaseandmaleinfertility.ThePI3K/AktsignalingpathwayplaysanimportantroleinregulatingARactivitythroughphosphorylationofARatSer213/210andSer791/790.GrowthfactorsorcytokinesmayinducephosphorylationofARthroughthePI3K/Aktpathway.ActivationofthePI3K/AKtpathwayisthoughttohaveasurvivalroleinprostatecancerbyprotectingcellsfromapoptosis.Anti-AndrogenReceptorAntibodyisidealforinvestigatorsinvolvedinneuroscience,cytokinesandgrowthfactors,andtranscriptionfactors.

Synonyms

rabbitAnti-AndrogenReceptorpY267antibody,Dihydrotestosteronereceptor,DHTR,NR3C4,rabbitAnti-ARpY267Antibody

Immunogen

Anti-AndrogenReceptorpY267affinitypurifiedantibodywaspreparedfromwholerabbitserumproducedbyrepeatedimmunizationswithasyntheticpeptidecorrespondingtotheinternalregionofhumanANDRprotein.

ImmunogenType

Peptide

StorageCondition

StoreARAntibodyat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.

ApplicationNote

Anti-AndrogenReceptorantibodyisusefulforELISA,Immunohistochemistry,andWesternBlot.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectabandapproximately~99kDacorrespondingtotheappropriatecelllysateorextract.

Purity/Specifity

Anti-AndrogenReceptorpY267wasaffinitypurifiedfrommonospecificantiserumbyimmunoaffinitychromatography.ABLASTanalysiswasusedtosuggestcross-reactivitywithhumanandchimpanzeebasedon100%sequencehomology.Cross-reactivitywithAndrogenReceptorpY267fromothersourceshasnotbeendetermined.

DisclaimerNote-General

Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.Theprospectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.

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Rockland/AR Phospho pY267 Antibody/600401J95/50 µg

ARPhosphopY267AntibodyProperties

ARPhosphopY267AntibodyDescription