Rockland/APOE Antibody/600401Y48/100 µg

APO-EAntibodyProperties

Description

Anti-APO-E(RABBIT)Antibody-600-401-Y48

Host

Rabbit

TargetSpecies

Human

KnownCrossReactivity

Human,mouse,rat

Clonality

Polyclonal

Application

ELISA:1:10,000-1:20,000
WesternBlot:1-2µg/mL

PhysicalState

Liquid(sterilefiltered)

ShippingCondition

DryIce

Format

IgG

Label

Unconjugated

Concentration

1mg/mLbyUVabsorbanceat280nm

Buffer

0.01MSodiumPhosphate,0.25MSodiumChloride,pH7.2

Preservative

0.02%(w/v)SodiumAzide

Stabilizer

None

GeneName

APOE

RelevantLinks

UniProtKB-P02649
GeneID-348
NCBI-NP_000032

APO-EAntibodyDescription

Background

Chylomicronremnantsandverylowdensitylipoprotein(VLDL)remnantsarerapidlyremovedfromthecirculationbyreceptor-mediatedendocytosisintheliver.ApolipoproteinE(APO-E),amainapoproteinofthechylomicron,bindstoaspecificreceptoronlivercellsandperipheralcellsandisessentialforthenormalcatabolismoftriglyceride-richlipoproteinconstituents.DefectsinAPO-Eresultinfamilialdysbetalipoproteinemia,ortypeIIIhyperlipoproteinemia(HLPIII),inwhichincreasedplasmacholesterolandtriglyceridesaretheconsequenceofimpairedclearanceofchylomicronandVLDLremnants.

Synonyms

APO-EAntibody,AD2,LPG,LDLCQ5,ApolipoproteinE,Apo-E

Immunogen

Anti-APO-Eantibodywaspreparedfromwholerabbitserumproducedbyrepeatedimmunizationswitha19aminoacidpeptideneartheC-terminusofhumanAPO-E.

ImmunogenType

Peptide

StorageCondition

Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.

ApplicationNote

Anti-APO-EAntibodyhasbeentestedforuseinELISA,WesternBlotting,andImmunohistochemistry.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectabandatapproximately36kDainWesternBlotsofspecificcelllysatesandtissues.

Purity/Specifity

Anti-APO-EAntibodywasaffinitypurifiedfrommonospecificantiserumbyimmunoaffinitychromatography.CrossreactivitywithAPO-Efromothersourceshasnotbeendetermined.

DisclaimerNote-General

Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.Theprospectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.

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Rockland/APOE Antibody/600401Y48/100 µg

APO-EAntibodyProperties

APO-EAntibodyDescription