Rockland/APOLIPOPROTEINCIII Antibody/600101114/1 mg

APOLIPOPROTEINC-IIIAntibodyProperties

Description

Anti-ApolipoproteinC-III(GOAT)Antibody-600-101-114

Host

Goat

TargetSpecies

Human

KnownCrossReactivity

human

Clonality

Polyclonal

Application

ELISA:1:5,000-1:10,000
WesternBlot:1:500-1:5,000
Immunohistochemistry:1:50-1:200
ImmunoPrecipitation:1:100
OtherDilution:UserOptimized

PhysicalState

Liquid(sterilefiltered)

ShippingCondition

WetIce

Format

IgG

Label

Unconjugated

Concentration

1.0mg/mLbyUVabsorbanceat280nm

Buffer

0.125MSodiumBorate,0.075MSodiumChloride,0.005MEDTA,pH8.0

Preservative

0.01%(w/v)SodiumAzide

Stabilizer

None

GeneName

APOC3

RelevantLinks

UniProtKB-P02656
NCBI-CAA25648.1
GeneID-345

APOLIPOPROTEINC-IIIAntibodyDescription

Background

AntiApolipoproteinC-IIIantibodyrecognizesthegeneproductofAPOC.ApolipoproteinC-IIIisaproteincomponentofverylowdensitylipoprotein(VLDL).APOC3inhibitslipoproteinlipaseandhepaticlipase;itisthoughttoinhibithepaticuptakeoftriglyceride-richparticles.TheAPOA1,APOC3andAPOA4genesarecloselylinkedinbothratandhumangenomes.TheA-IandA-IVgenesaretranscribedfromthesamestrand,whiletheA-1andC-IIIgenesareconvergentlytranscribed.AnincreaseinapoC-IIIlevelsinducesthedevelopmentofhypertriglyceridemia.Thisantibodyissuitableforcardiovascularresearch.

Synonyms

goatanti-ApolipoproteinC-IIIantibody,ApoC-III,Apo-CIIIantibody,ApolipoproteinC3,ApolipoproteinCIIIantibody

Immunogen

producedfromapoLipoproteinTypeC-IIIderivedfromhumanplasma

ImmunogenType

NativeProtein

StorageCondition

Storevialat4°Cpriortoopening. Thisproductisstable4°Casanundilutedliquid. Diluteonlypriortoimmediateuse. Forextendedstoragemixwithanequalvolumeofglycerol,aliquotcontentsandfreezeat-20°Corbelow. Avoidcyclesoffreezingandthawing.

ApplicationNote

Anti-ApolipoproteinantibodieshavebeenusedforindirecttrappingELISAforquantitationofantigeninserumusingastandardcurve,immunoprecipitation,immunohistochemistry,andforwesternblottingforhighlysensitivequalitativeanalysis.Whenperformingimmunoblottingassays-donotblockwithblotto.BlottoformulationstendtocontainapoLipoproteinTypeC-IIIandwillneutralizeantibodyactivity.

Purity/Specifity

Thisproducthasbeenpreparedbyimmunoaffinitychromatographyusingimmobilizedantigensfollowedbyextensivecross-adsorptionagainstotherapoLipoproteinsandhumanserumproteinstoremoveanyunwantedspecificities. Typicallylessthan1%crossreactivityagainstothertypesofapoLipoproteinwasdetectedbyELISAagainstpurifiedstandards. ThisantibodyreactswithhumanapoLipoproteinC-IIIandhasnegligiblecross-reactivitywithTypeA-I,A-II,B,C-I,C-II,EandJapoLipoproteins. Specificcrossreactionofanti-apoLipoproteinantibodieswithantigensfromotherspecieshasnotbeendetermined. Non-specificcrossreactionofanti-apoLipoproteinantibodieswithotherhumanserumproteinsisnegligible.

DisclaimerNote-General

Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.Theprospectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.

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Rockland/APOLIPOPROTEINCIII Antibody/600101114/1 mg

APOLIPOPROTEINC-IIIAntibodyProperties

APOLIPOPROTEINC-IIIAntibodyDescription