Rockland/ABCB8 Antibody/100401P00/100 µL

ABCB8AntibodyProperties

Description

Anti-ABCB8(RABBIT)Antibody-100-401-P00

Host

Rabbit

TargetSpecies

Human

KnownCrossReactivity

Human

Clonality

Polyclonal

Application

ELISA:1:20,000-1:50,000
WesternBlot:1:250-1:500

SpeciesofOrigin

Rabbit

PhysicalState

Liquid(sterilefiltered)

ShippingCondition

DryIce

Format

IgG

Label

Unconjugated

Concentration

80mg/mLbyRefractometry

Buffer

0.02MPotassiumPhosphate,0.15MSodiumChloride,pH7.2

Preservative

0.01%(w/v)SodiumAzide

Stabilizer

None

GeneName

ABCB8

RelevantLinks

UniProtKB-Q9NUT2
NCBI-NP_009119.2
GeneID-11194

ABCB8AntibodyDescription

Background

Thisantibodyisdesigned,produced,andvalidatedaspartofacollaborationbetweenRocklandandtheNationalCancerInstitute(NCI)andissuitableforCancerResearchanddrugresistance.ABCB8isdesigned,produced,andvalidatedaspartofacollaborationbetweenRocklandandtheNationalCancerInstitute(NCI).IthasbeenfoundthatABCtransportersareinvolvedinmulitdrugresistancethroughtheirabilitytocontolthepresenceofdrugsincells.Multidrugresistanceiscurrentlybeinglookedatinparticularreferencetocancerthatisresistanttotreatment.ABCB8seemstohaveparticulalrlyhighresistanceratesinrenalcancerandcancerofthecentralnervoussystem.AnothersignificantaspectofABCB8isthatitisamitochondrialtransporter.ThereareveryfewABCtransporterslocalizedtothemitochondriawhichimpliesinformationaboutthemcouldbeextremelyimportant.ABCB8mayalsobelocalizedtootherpartsofthecellwhichareyettobedetermined.Anti-ABCB8antibodyisidealforresearchersnterestedinCancerResearchanddrugresistance.

Synonyms

Rabbitanti-ABCB8antibody,ATP-bindingcassettesub-familyBmember8mitochondrial,MitochondrialATP-bindingcassette1,M-ABC1,ABCB-8,ABCB

Immunogen

ABCB8waspreparedfromwholerabbitserumproducedbyrepeatedimmunizationswithasyntheticpeptidecorrespondingtoainternalportionofhumanABCB8.

ImmunogenType

Peptide

StorageCondition

Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.

ApplicationNote

Anti-ABCB8antibodyhasbeentestedforuseinELISAandwesternblotting.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectbandapproximately79.9kDainsizecorrespondingtoABCB8bywesternblottingintheappropriatecelllysateorextract.

Purity/Specifity

Anti-ABCB8Antibodywaspreparedfrommonospecific,delipidatedanddefibrinatedantiserum,withadditionofsodiumazideto0.01%.ABLASTanalysiswasusedtosuggestcross-reactivitywithABCB8fromhuman,mouse,andratbasedona100%homologywiththeimmunizingsequence.Reactivityagainsthomologuesfromothersourcesisnotknown.TheantibodydetectsABCB8incelllysates.

DisclaimerNote-General

Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.Theprospectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.

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Rockland/ABCB8 Antibody/100401P00/100 µL

ABCB8AntibodyProperties

ABCB8AntibodyDescription