Rockland/Anosmin Antibody/600401Y18/100 µg

AnosminAntibodyProperties

Description

Anti-Anosmin(RABBIT)Antibody-600-401-Y18

Host

Rabbit

TargetSpecies

Human

KnownCrossReactivity

Human

Clonality

Polyclonal

Application

ELISA:1:10,000
IFMicroscopy:20µg/mL
WesternBlot:1µg/mL
Immunohistochemistry:5µg/mL

PhysicalState

Liquid(sterilefiltered)

ShippingCondition

DryIce

Format

IgG

Label

Unconjugated

Concentration

1mg/mLbyUVabsorbanceat280nm

Buffer

0.01MSodiumPhosphate,0.25MSodiumChloride,pH7.2

Preservative

0.02%(w/v)SodiumAzide

Stabilizer

None

GeneName

KAL1

RelevantLinks

UniProtKB-P23352
GeneID-3730
NCBI-NP_000207

AnosminAntibodyDescription

Background

MutationsinAnosmin-1,anextracellularmatrix-associatedglycosylatedprotein,havebeenlinkedwithKallmannSyndrome(KS),anX-linkedgeneticdisordercharacterizedbylossofsmellcausedbyabnormalolfactorybulbdevelopmentanddelayedpubertycausedbydisruptedmigrationofthegonadotropin-releasinghormoneneuron.Anosmin-1hasbeenshowntodirectlybindFGFR1viaitsN-terminalcysteine-richdomain,whey-acidicprotein-likedomain,anditsfirstFnIIIrepeatwiththeD2andD3ectodomainsofFGFR1.ItisthoughtthatAnosmin-1canmodulateFGFR1signalingandhaveopposingeffectsontheformationandactivationofFGF2-FGFR1-heparingcomplex.

Synonyms

AnosminAntibody,HH1,HHA,KAL,KMS,ADMLX,WFDC19,KALIG-1,KALIG1,Anosmin-1,Adhesionmolecule-likeX-linked

Immunogen

Anti-Anosminantibodywaspreparedfromwholerabbitserumproducedbyrepeatedimmunizationswithan18aminoacidsyntheticpeptideneartheinternalregionofhumanAnosmin.

ImmunogenType

Peptide

StorageCondition

Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.

ApplicationNote

Anti-AnosminAntibodyhasbeentestedforuseinELISA,WesternBlotting,ImmunocytochemistryandImmunofluorescence.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectabandatapproximately76kDainWesternBlotsofspecificcelllysatesandtissues.

Purity/Specifity

Anti-AnosminAntibodywasaffinitypurifiedfrommonospecificantiserumbyimmunoaffinitychromatography.CrossreactivitywithAnosminfromothersourceshasnotbeendetermined.

DisclaimerNote-General

Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.Theprospectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.

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Rockland/Anosmin Antibody/600401Y18/100 µg

AnosminAntibodyProperties

AnosminAntibodyDescription