Rockland/5Lipoxygenase phospho S523 Antibody/600401D03/100 µL

5-LipoxygenasephosphoS523AntibodyProperties

Description

Anti-5-LipoxygenasepS523(Rabbit)Antibody-600-401-D03

Host

Rabbit

TargetSpecies

Human

KnownCrossReactivity

human,rat,mouse

Clonality

Polyclonal

Application

ELISA:1:10,000
WesternBlot:1:1000

PhysicalState

Liquid

ShippingCondition

DryIce

Format

IgG

Label

Unconjugated

Buffer

0.01MHEPES,0.15MSodiumChloride,pH7.5

Stabilizer

0.1mg/mlBovineSerumAlbumin(BSA)-IgGandProteasefree,50%(v/v)Glycerol

GeneName

ALOX5

RelevantLinks

UniProtKB-P09917
GeneID-240
UniProtKB-P09917.2

5-LipoxygenasephosphoS523AntibodyDescription

Background

5-LipoxygenasepS523antibodyrecognizestheenzyme5-lipoxygenase(5-LO)whichplaysakeyroleinregulatingtheproductionofleukotrienes(LTs).OverproductionofLTscontributestoseveraldiseases,mostnotablychronicinflammatorydiseases,includingasthma,fibrosisandatherosclerosis.Recentworkhasdemonstratedthattheactivityof5-LOisregulatedbyPKAphosphorylationofserine-523in5-LO.Undernormalconditions,thisphosphorylationmaybeimportantinlimitinginflammation.AbnormalsignalingthroughcAMPandPKA,then,couldcontributetoavarietyofdiseases,includingthosecharacterizedbychronicinflammation.Thephospho-specificantibodytoSer523on5-LOisthuslikelytoprovideavaluabletoolforstudiesoftheroleof5-LOregulationindiseasessuchasasthma,fibrosisandatherosclerosis.Anti-5-LipoxygenasepS523antibodyisidealforinvestigatorsinvolvedinCellSignaling,Neuroscience,SignalTransductionresearch.

Synonyms

Arachidonate5-lipoxygenase,5-LO

Immunogen

Anti-5-LipoxygenasepS523Antibodywasproducedbyrepeatedimmunizationswithsyntheticphospho-peptidecorrespondingtoaminoacidresiduessurroundingSer523.

ImmunogenType

Peptide

PostTranslationalModification

Phosphorylation

StorageCondition

Storevialat-20°Cpriortoopening. Thisproductisstableat4°Casanundilutedliquid. Forextendedstorage,aliquotcontentsandfreezeat-20°Corbelow. Avoidcyclesoffreezingandthawing.Diluteonlypriortoimmediateuse.

ApplicationNote

Anti-5-LipoxygenasepS523antibodyissuitableforuseinWesternBlottingandELISA.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectabandofapproximately80kDacorrespondingtothe80kDa5-LOproteinsphosphorylatedatSer523.

Purity/Specifity

Anti-5-LipoxygenasepS523Antibodyisdirectedagainsthuman5-LipoxygenasephosphorylatedatS523.Theantibodyisaffinitypurifiedfrommonospecificantiserumbyimmunoaffinitypurification.Reactivityisexpectedfromthefollowingspeciesbasedon100%sequencehomology:nonhumanprimates.Crossreactivitywith5-LipoxygenasepS523fromotherspecieshasnotbeendetermined.

DisclaimerNote-General

Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.Theprospectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.

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Rockland/5Lipoxygenase phospho S523 Antibody/600401D03/100 µL

5-LipoxygenasephosphoS523AntibodyProperties

5-LipoxygenasephosphoS523AntibodyDescription